This database contains 750 studies, archived under the term: "aged, 80 and over"
Click here to filter this large number of results.
The dementia antipsychotic withdrawal trial (DART-AD): long-term follow-up of a randomised placebo-controlled trial
Ballard, Clive,
Hanney, Maria Luisa,
Theodoulou, Megan,
Douglas, Simon,
McShane, Rupert,
Kossakowski, Katja,
Gill, Randeep,
Juszczak, Edmund,
Yu, Ly-Mee,
Jacoby, Robin
Background: Data from 12-week placebo-controlled trials have led to mounting concerns about increased mortality in patients with Alzheimer’s disease (AD) who are prescribed antipsychotics; however, there are no mortality data from long-term placebo-controlled trials. We aimed to assess whether continued treatment with antipsychotics in people with AD is associated with an increased risk of mortality.; […]
Prediction of amyloid-β pathology in amnestic mild cognitive impairment with neuropsychological tests
Bahar-Fuchs, Alex,
Villemagne, Victor,
Ong, Kevin,
Chetélat, Gaël,
Lamb, Fiona,
Reininger, Cornelia B.,
Woodward, Michael,
Rowe, Christopher C.
Assessment of disease biomarkers, particularly the in vivo assessment of amyloid-β (Aβ) burden with positron emission tomography (PET), is gradually becoming central to the diagnosis of mild cognitive impairment (MCI) due to Alzheimer’s disease (AD). However, the incorporation of biomarker evidence to the diagnostic process is currently restricted mainly to research settings. The identification of […]
The Coping with Caregiving Group Program for Chinese caregivers of patients with Alzheimer’s disease in Hong Kong
Au, Alma,
Li, Sapphire,
Lee, Kristy,
Leung, Patrick,
Pan, Pey-Chyou,
Thompson, Larry,
Gallagher-Thompson, Dolores
Objective: This pilot study evaluated the effectiveness of Coping with Caregiving (CWC) psychoeducational program for Chinese family caregivers of patients with Alzheimer’s disease in Hong Kong.; Method: Twenty-seven female primary caregivers were randomized to join the treatment group or wait-list control group. The caregivers in the treatment group participated in 13 weekly training sessions which […]
Measuring memory in large group settings using a continuous recognition test
Memory function generally deteriorates with age, and memory impairments are a common symptom of serious illness such as dementia. Although screening tests are widely used throughout Medicine, they are not yet commonly used to detect memory impairments. The objective of this study was to characterize an audience-based memory test suitable for administration to a large […]
Dietary intake of vitamin D and cognition in older women: a large population-based study
Annweiler, C.,
Schott, A.M.,
Rolland, Y.,
Blain, H.,
Herrmann, F. R.,
Beauchet, O.
Background: Serum vitamin D concentrations are associated with global cognitive function among older adults. The benefits of vitamin D intake to treat or prevent cognitive impairment remain unknown. The objective of this cross-sectional study was to determine whether weekly dietary intake of vitamin D could be associated with global cognitive performance among older adults.; Methods: […]
Serum vitamin D deficiency as a predictor of incident non-Alzheimer dementias: a 7-year longitudinal study
Annweiler, C.,
Rolland, Y.,
Schott, A.M.,
Blain, H.,
Vellas, B.,
Beauchet, O.
Background: Hypovitaminosis D has been cross-sectionally associated with dementia and stroke. The objective of this longitudinal study was to determine whether serum vitamin D deficiency at baseline could predict the onset of non-Alzheimer dementias (NAD) within 7 years among older women.; Methods: Forty high-functioning older women (78.4 years, 76.4/82.0; median, 25th/75th percentile) from the EPIDOS […]
Exergaming and older adult cognition: a cluster randomized clinical trial
Anderson-Hanley, Cay,
Arciero, Paul J.,
Brickman, Adam M.,
Nimon, Joseph P.,
Okuma, Naoko,
Westen, Sarah C.,
Merz, Molly E.,
Pence, Brandt D.,
Woods, Jeffrey A.,
Kramer, Arthur F.,
Zimmerman, Earl A.
Background: Dementia cases may reach 100 million by 2050. Interventions are sought to curb or prevent cognitive decline. Exercise yields cognitive benefits, but few older adults exercise. Virtual reality-enhanced exercise or “exergames” may elicit greater participation.; Purpose: To test the following hypotheses: (1) stationary cycling with virtual reality tours (“cybercycle”) will enhance executive function and […]
Neuropsychological assessment of driving safety risk in older adults with and without neurologic disease
Anderson, Steven W.,
Aksan, Nazan,
Dawson, Jeffrey D.,
Uc, Ergun Y.,
Johnson, Amy M.,
Rizzo, Matthew
Decline in cognitive abilities can be an important contributor to the driving problems encountered by older adults, and neuropsychological assessment may provide a practical approach to evaluating this aspect of driving safety risk. The purpose of the present study was to evaluate several commonly used neuropsychological tests in the assessment of driving safety risk in […]