Hankey, Graeme J., Ford, Andrew H., Yi, Qilong, Eikelboom, John W., Lees, Kennedy R., Chen, Christopher, Xavier, Denis, Navarro, Jose C., Ranawaka, Udaya K., Uddin, Wasim, Ricci, Stefano, Gommans, John, Schmidt, Reinhold, Almeida, Osvaldo P., van Bockxmeer, Frank M.

Background and Purpose: High plasma total homocysteine (tHcy) has been associated with cognitive impairment but lowering tHcy with B-vitamins has produced equivocal results. We aimed to determine whether B-vitamin supplementation would reduce tHcy and the incidence of new cognitive impairment among individuals with stroke or transient ischemic attack≥6 months previously.; Methods: A total of 8164 […]

Román, Gustavo C., Salloway, Stephen, Black, Sandra E., Royall, Donald R., DeCarli, Charles, Weiner, Michael W., Moline, Margaret, Kumar, Dinesh, Schindler, Rachel, Posner, Holly

Background and Purpose: We sought to assess the efficacy and safety of donepezil in patients with vascular dementia (VaD) fulfilling National Institute of Neurological Disorders and Stroke-Association Internationale pour la Recherche et l’Enseignement en Neurosciences criteria.; Methods: This international, multicenter, 24-week trial was conducted from March 2003 to August 2005. Patients (N=974; mean age, 73.0 […]

Richard, E., Gouw, A. A., Scheltens, P., van Gool, W. A.

Background and Purpose: White matter lesions (WMLs) and cerebral infarcts are common findings in Alzheimer disease and may contribute to dementia severity. WMLs and lacunar infarcts may provide a potential target for intervention strategies. This study assessed whether multicomponent vascular care in patients with Alzheimer disease with cerebrovascular lesions slows progression of WMLs and prevents […]

Pendlebury, S. T., Cuthbertson, F. C., Welch, S. J. V., Mehta, Z., Rothwell, P. M.

Background and Purpose: The Mini-Mental State Examination (MMSE) is insensitive to mild cognitive impairment and executive function. The more recently developed Montreal Cognitive Assessment (MoCA), an alternative, brief 30-point global cognitive screen, might pick up more cognitive abnormalities in patients with cerebrovascular disease.; Methods: In a population-based study (Oxford Vascular Study) of transient ischemic attack […]