Nichols, Linda Olivia, Martindale-Adams, Jennifer, Burns, Robert, Graney, Marshall J., Zuber, Jeffrey

Background: Based on the National Institute on Aging/National Institute of Nursing Research Resources for Enhancing Alzheimer’s Caregiver Health (REACH) randomized controlled trial (REACH II), REACH VA (Department of Veterans Affairs) was the first national clinical translation of a proven behavioral intervention for dementia caregivers, running from September 2007 through August 2009. This article describes the […]

Llewellyn, David J., Lang, Iain A., Langa, Kenneth M., Muniz-Terrera, Graciela, Phillips, Caroline L., Cherubini, Antonio, Ferrucci, Luigi, Melzer, David

Background: To our knowledge, no prospective study has examined the association between vitamin D and cognitive decline or dementia.; Methods: We determined whether low levels of serum 25-hydroxyvitamin D (25[OH]D) were associated with an increased risk of substantial cognitive decline in the InCHIANTI population-based study conducted in Italy between 1998 and 2006 with follow-up assessments […]

Dechamps, Arnaud, Diolez, Philippe, Thiaudière, Eric, Tulon, Aurore, Onifade, Chérifa, Vuong, Tuan, Helmer, Catherine, Bourdel-Marchasson, Isabelle

Background: Our objective was to assess the effects of targeted exercise programs on health-related quality of life compared with usual care based on the ability to perform activities of daily living (ADL) and the Neuropsychiatric Inventory scores in geriatric institutionalized persons.; Methods: A randomized controlled trial of 2 exercise programs vs usual care was conducted […]

Sink, Kaycee M., Leng, Xiaoyan, Williamson, Jeff, Kritchevsky, Stephen B., Yaffe, Kristine, Kuller, Lewis, Yasar, Sevil, Atkinson, Hal, Robbins, Mike, Psaty, Bruce, Goff, David C.

Background: Hypertension (HTN) is a risk factor for dementia, and animal studies suggest that centrally active angiotensin-converting enzyme (ACE) inhibitors (those that cross the blood-brain barrier) may protect against dementia beyond HTN control.; Methods: Participants in the Cardiovascular Health Study Cognition Substudy with treated HTN and no diagnosis of congestive heart failure (n = 1054; […]