This database contains 162 studies, archived under the term: "Diagnostic Target Identification"
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A comparison of performance-based measures of function in HIV-associated neurocognitive disorders
Gandhi, Nishiena S.,
Skolasky, Richard L.,
Peters, Katherine B.,
Moxley, Richard T. th,
Creighton, Jason,
Roosa, Heidi Vornbrock,
Selnes, Ola A.,
McArthur, Justin,
Sacktor, Ned
The objectives of this study are to compare the results of newer performance-based functional assessments in the study of HIV-associated neurocognitive disorders (HAND) and to correlate these functional assessments with specific levels of severity of HAND. One hundred fourteen HIV+ subjects in an existing cohort were evaluated with a medical history, neurological exam, neuropsychological test […]
The Indiana University Cognitive Health Outcomes Investigation of the Comparative Effectiveness of dementia screening (CHOICE) study: study protocol for a randomized controlled trial
Fowler, Nicole R.,
Harrawood, Amanda,
Frame, Amie,
Perkins, Anthony J.,
Gao, Sujuan,
Callahan, Christopher M.,
Sachs, Greg A.,
French, Dustin D.,
Boustani, Malaz A.
Background: Dementia affects over 4 million people in the US and is frequently unrecognized and underdiagnosed in primary care. Routine dementia screening in primary care is not recommended by the US Preventive Services Task Force due to lack of empirical data on the benefits and harms of screening. This trial seeks to fill this gap […]
Validation of AclarusDx™, a blood-based transcriptomic signature for the diagnosis of Alzheimer’s disease
Fehlbaum-Beurdeley, Pascale,
Sol, Olivier,
Désiré, Laurent,
Touchon, Jacques,
Dantoine, Thierry,
Vercelletto, Martine,
Gabelle, Audrey,
Jarrige, Anne-Charlotte,
Haddad, Raphaël,
Lemarié, Jean Christophe,
Zhou, Weiyin,
Hampel, Harald,
Einstein, Richard,
Vellas, Bruno
Biomarkers have gained an increased importance in the past years in helping physicians to diagnose Alzheimer’s disease (AD). This study was designed to identify a blood-based, transcriptomic signature that can differentiate AD patients from control subjects. The performance of the signature was then evaluated for robustness in an independent blinded sample population. RNA was extracted […]
Influence of social support on cognitive change and mortality in old age: results from the prospective multicentre cohort study AgeCoDe
Eisele, Marion,
Zimmermann, Thomas,
Köhler, Mirjam,
Wiese, Birgitt,
Heser, Kathrin,
Tebarth, Franziska,
Weeg, Dagmar,
Olbrich, Julia,
Pentzek, Michael,
Fuchs, Angela,
Weyerer, Siegfried,
Werle, Jochen,
Leicht, Hanna,
König, Hans-Helmut,
Luppa, Melanie,
Riedel-Heller, Steffi,
Maier, Wolfgang,
Scherer, Martin
Background: Social support has been suggested to positively influence cognition and mortality in old age. However, this suggestion has been questioned due to inconsistent operationalisations of social support among studies and the small number of longitudinal studies available. This study aims to investigate the influence of perceived social support, understood as the emotional component of […]
The NIH stroke scale can establish cognitive function after stroke
Background: Cognitive impairment is an important but underrecognised consequence of stroke. We investigated whether a subset of items from the NIH Stroke Scale (NIHSS) could yield valid information on cognitive status in a group of stroke patients.; Methods: 149 stroke patients from the Göteborg 70+ Stroke Study were investigated after 18 months. We extracted 4 […]
Public-private partnerships improve health outcomes in individuals with early stage Alzheimer’s disease
Purpose: In a collaborative effort between the Missouri Department of Health, Area Agencies on Aging (AAA), Alzheimer Association, and academic researchers, we tested whether early dementia detection and comprehensive care consultations would improve health outcomes in care receivers (CRs) and their family caregivers (FCGs), therefore addressing an important public health concern.; Participants and Methods: A […]
Voxel-level comparison of arterial spin-labeled perfusion MRI and FDG-PET in Alzheimer disease
Chen, Y.,
Wolk, D. A.,
Reddin, J. S.,
Korczykowski, M.,
Martinez, P. M.,
Musiek, E. S.,
Newberg, A. B.,
Julin, P.,
Arnold, S. E.,
Greenberg, J. H.,
Detre, J. A.
Objective: We compared the ability of arterial spin labeling (ASL), an MRI method that measures cerebral blood flow (CBF), to that of FDG-PET in distinguishing patients with Alzheimer disease (AD) from healthy, age-matched controls.; Methods: Fifteen patients with AD (mean age 72 ± 6 years, Mini-Mental State Examination score [MMSE] 20 ± 6) and 19 […]
Is emotional memory enhancement preserved in amnestic mild cognitive impairment? Evidence from separating recollection and familiarity
Wang, Pengyun,
Li, Juan,
Li, Huijie,
Li, Bing,
Jiang, Yang,
Bao, Feng,
Zhang, Shouzi
Objective: This study investigated whether the observed absence of emotional memory enhancement in recognition tasks in patients with amnestic mild cognitive impairment (aMCI) could be related to their greater proportion of familiarity-based responses for all stimuli, and whether recognition tests with emotional items had better discriminative power for aMCI patients than those with neutral items.; […]
Diagnostic accuracy of the Phototest for cognitive impairment and dementia in Argentina
Russo, María Julieta,
Iturry, Mónica,
Sraka, María Alejandra,
Bartoloni, Leonardo,
Carnero Pardo, Cristóbal,
Allegri, Ricardo Francisco
Phototest is a simple, easy and very brief test with theoretical advantages over available dementia screening tests in Spain. The objective of this study was to estimate the diagnostic accuracy of the Phototest for cognitive impairment and dementia and to compare it with that of the MMSE and the Clock Drawing Test (CDT) in an […]