This database contains 162 studies, archived under the term: "Diagnostic Target Identification"
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Prediction of dementia in primary care patients
Jessen, Frank,
Wiese, Birgitt,
Bickel, Horst,
Eiffländer-Gorfer, Sandra,
Fuchs, Angela,
Kaduszkiewicz, Hanna,
Köhler, Mirjam,
Luck, Tobias,
Mösch, Edelgard,
Pentzek, Michael,
Riedel-Heller, Steffi G.,
Wagner, Michael,
Weyerer, Siegfried,
Maier, Wolfgang,
van den Bussche, Hendrik
Background: Current approaches for AD prediction are based on biomarkers, which are however of restricted availability in primary care. AD prediction tools for primary care are therefore needed. We present a prediction score based on information that can be obtained in the primary care setting.; Methodology/principal Findings: We performed a longitudinal cohort study in 3.055 […]
Population screening for variant Creutzfeldt-Jakob disease using a novel blood test: diagnostic accuracy and feasibility study
Jackson, Graham S.,
Burk-Rafel, Jesse,
Edgeworth, Julie Ann,
Sicilia, Anita,
Abdilahi, Sabah,
Korteweg, Justine,
Mackey, Jonathan,
Thomas, Claire,
Wang, Guosu,
Schott, Jonathan M.,
Mummery, Catherine,
Chinnery, Patrick F.,
Mead, Simon,
Collinge, John
Importance: Our study indicates a prototype blood-based variant Creutzfeldt-Jakob disease (vCJD) assay has sufficient sensitivity and specificity to justify a large study comparing vCJD prevalence in the United Kingdom with a bovine spongiform encephalopathy-unexposed population. In a clinical diagnostic capacity, the assay’s likelihood ratios dramatically change an individual’s pretest disease odds to posttest probabilities and […]
Ankle blood pressure and dementia: a prospective follow-up study
Background and Objective: Ankle blood pressure may be a useful indicator of arterial stiffness. The main aim of the present study was to examine the relationship of ankle blood pressure measured in midlife with the risk of dementia with advancing age. A secondary aim was to examine the relationship of physical exercise capacity in midlife […]
Altered microstructure in corticospinal tract in idiopathic normal pressure hydrocephalus: comparison with Alzheimer disease and Parkinson disease with dementia
Hattori, T.,
Yuasa, T.,
Aoki, S.,
Sato, R.,
Sawaura, H.,
Mori, T.,
Mizusawa, H.
Background and Purpose: Previous neuropathologic studies in chronic hydrocephalus have suggested the presence of white matter damage, presumably from mechanical pressure due to ventricular enlargement and metabolic derangement. This study aimed to investigate the diffusional properties of the CST in patients with iNPH by using DTI and to determine whether this method could be used […]
Plasma proteomics for the identification of Alzheimer disease
Less-invasive biomarkers for early Alzheimer disease (AD) are urgently needed. The present study aimed to establish a panel of plasma proteins that accurately distinguishes early AD from physiological aging and to compare the findings with previous reports. Fifty-eight healthy controls (CON) and 109 patients with AD dementia were randomly split into a training (40%) and […]
Japanese-English language equivalence of the Cognitive Abilities Screening Instrument among Japanese-Americans
Gibbons, Laura E.,
McCurry, Susan,
Rhoads, Kristoffer,
Masaki, Kamal,
White, Lon,
Borenstein, Amy R.,
Larson, Eric B.,
Crane, Paul K.
Background: The Cognitive Abilities Screening Instrument (CASI) was designed for use in cross-cultural studies of Japanese and Japanese-American elderly in Japan and the U.S.A. The measurement equivalence in Japanese and English had not been confirmed in prior studies.; Methods: We analyzed the 40 CASI items for differential item functioning (DIF) related to test language, as […]
Brief screening tool for mild cognitive impairment in older Japanese: validation of the Japanese version of the Montreal Cognitive Assessment
Fujiwara, Yoshinori,
Suzuki, Hiroyuki,
Yasunaga, Masashi,
Sugiyama, Mika,
Ijuin, Mutsuo,
Sakuma, Naoko,
Inagaki, Hiroki,
Iwasa, Hajime,
Ura, Chiaki,
Yatomi, Naomi,
Ishii, Kenji,
Tokumaru, Aya M,
Homma, Akira,
Nasreddine, Ziad,
Shinkai, Shoji
Aim: The Montreal Cognitive Assessment (MoCA), developed by Dr Nasreddine (Nasreddine et al. 2005), is a brief cognitive screening tool for detecting older people with mild cognitive impairment (MCI). We examined the reliability and validity of the Japanese version of the MoCA (MoCA-J) in older Japanese subjects.; Methods: Subjects were recruited from the outpatient memory […]
Object alternation: a novel probe of medial frontal function in frontotemporal dementia
Freedman, Morris,
Binns, Malcolm A.,
Black, Sandra E.,
Levine, Brian,
Miller, Bruce L.,
Ramirez, Joel,
Szilagyi, Gregory M.,
Scott, Christopher J. M.,
McNeely, Alicia A.,
Stuss, Donald T.
We studied behavioral variant frontotemporal dementia (bvFTD) using object alternation (OA) as a novel probe of cognition. This task was adopted from animal models and is sensitive to ventrolateral-orbitofrontal and medial frontal function in humans. OA was administered to bvFTD patients, normal controls, and a dementia control group with Alzheimer disease (AD). Two other frontal […]