Cukierman-Yaffe, Tali, Gerstein, Hertzel C., Williamson, Jeff D., Lazar, Ronald M., Lovato, Laura, Miller, Michael E., Coker, Laura H., Murray, Anne, Sullivan, Mark D., Marcovina, Santica M., Launer, Lenore J.

Objective: Diabetes is associated with cognitive decline and dementia. However, the relationship between the degree of hyperglycemia and cognitive status remains unclear. This was explored using baseline cognitive measures collected in the ongoing Memory in Diabetes (MIND) substudy of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial.; Research Design and Methods: The relationship […]

Mirelman, Anat, Rochester, Lynn, Reelick, Miriam, Nieuwhof, Freek, Pelosin, Elisa, Abbruzzese, Giovanni, Dockx, Kim, Nieuwboer, Alice, Hausdorff, Jeffrey M.

Background: Recent work has demonstrated that fall risk can be attributed to cognitive as well as motor deficits. Indeed, everyday walking in complex environments utilizes executive function, dual tasking, planning and scanning, all while walking forward. Pilot studies suggest that a multi-modal intervention that combines treadmill training to target motor function and a virtual reality […]

Rabey, Jose M., Dobronevsky, Evgenia, Aichenbaum, Sergio, Gonen, Ofer, Marton, Revital Gendelman, Khaigrekht, Michael

Cortical excitability can be modulated using repetitive transcranial magnetic stimulation (rTMS). Previously, we showed that rTMS combined with cognitive training (rTMS-COG) has positive results in Alzheimer’s disease (AD). The goal of this randomized double-blind, controlled study was to examine the safety and efficacy of rTMS-COG in AD. Fifteen AD patients received 1-h daily rTMS-COG or […]

Barak, Yoram, Plopski, Igor, Tadger, Shelly, Paleacu, Diana

Background: Antipsychotics are frequently used to treat psychosis, aggression and agitation in patients with Alzheimer’s disease (AD), but safety warnings abound. Escitalopram was investigated since citalopram has demonstrated some effectiveness in AD. We compared escitalopram and risperidone for psychotic symptoms and agitation associated with AD.; Methods: Inpatients with AD, who had been hospitalized because of […]