This database contains 60 studies, archived under the term: "France"
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A phase II trial of tideglusib in Alzheimer’s disease
Lovestone, Simon,
Boadab, Mercè,
Dubois, Bruno,
Hüll, Michael,
Rinne, Juha O.,
Huppertz, Hans-Jürgen,
Calero, Miguel,
Andrés, María V.,
Gómez-Carrillo, Belén,
Leon, Teresa,
del Seri, Teodoro
Background: The ARGO study was a phase II, double-blind, placebo controlled, four parallel arm trial of tideglusib in Alzheimer’s disease (AD). Objective: To prove the clinical efficacy of an inhibitor of glycogen synthase kinase-3 (GSK-3), in AD. Methods: Mild to moderate (Mini-Mental State Examination (MMSE) score, 14–26) AD patients on cholinesterase inhibitor and/or memantine treatment […]
Management of apathy in nursing homes using a teaching program for care staff: the STIM-EHPAD study
Leone, Elsa,
Deudon, Audrey,
Bauchet, Murielle,
Laye, Mathilde,
Bordone, Nathalie,
Lee, Ji-Hyun,
Piano, Julie,
Friedman, Leah,
David, Renaud,
Delva, Fleur,
Brocker, Patrice,
Yesavage, Jerome,
Robert, Philippe Henri
Objective: This study aimed to evaluate the effectiveness of a nursing home (NH) staff education to manage apathy in older individuals with a diagnosis of dementia.; Methods: Sixteen NHs agreed to participate, and 230 demented apathetic residents were randomly assigned to the reference group (RG) or the intervention group (IG). IG received a month of […]
Mediterranean diet and cognitive function: a French study
Kesse-Guyot, E.,
Andreeva, V. A.,
Lassale, C.,
Ferry, M.,
Jeandel, C.,
Hercberg, S.,
Galan, P.
Background: Evidence on the association between Mediterranean diet (MedDiet) adherence and cognition is presently inconsistent.; Objectives: The aims of this study were to investigate the association between midlife MedDiet adherence and cognitive performance assessed 13 y later among participants in the SU.VI.MAX (Supplementation with Vitamins and Mineral Antioxidants) study and to test the hypothesis of […]
Adverse drug reactions in elderly subjects hospitalized in a specialized dementia management unit
Kanagaratnam, Lukshe,
Mahmoudi, Rachid,
Novella, Jean-Luc,
Jolly, Damien,
Dramé, Moustapha,
Trenque, Thierry
Introduction: Drug prescriptions represent an actionable item in the prevention of adverse drug reactions (ADRs). The aims of this study were to identify risk factors for the occurrence of ADRs, and to describe symptoms and drug interactions. Methods: This was a longitudinal study over a period of 19 months in an acute geriatric ward specializing […]
Doxycycline in Creutzfeldt-Jakob disease: a phase 2, randomised, double-blind, placebo-controlled trial
Haïk, Stéphane,
Marcon, Gabriella,
Mallet, Alain,
Tettamanti, Mauro,
Welaratne, Arlette,
Giaccone, Giorgio,
Azimi, Shohreh,
Pietrini, Vladimiro,
Fabreguettes, Jean-Roch,
Imperiale, Daniele,
Cesaro, Pierre,
Buffa, Carlo,
Aucan, Christophe,
Lucca, Ugo,
Peckeu, Laurène,
Suardi, Silvia,
Tranchant, Christine,
Zerr, Inga,
Houillier, Caroline,
Redaelli, Veronica,
Vespignani, Hervé,
Campanella, Angela,
Sellal, François,
Krasnianski, Anna,
Seilhean, Danielle,
Heinemann, Uta,
Sedel, Frédéric,
Canovi, Mara,
Gobbi, Marco,
Di Fede, Giuseppe,
Laplanche, Jean-Louis,
Pocchiari, Maurizio,
Salmona, Mario,
Forloni, Gianluigi,
Brandel, Jean-Philippe,
Tagliavini, Fabrizio
Background: Creutzfeldt-Jakob disease (CJD) is a fatal, untreatable prion encephalopathy. Previous studies showed that doxycycline is effective in in-vitro and in-vivo models of disease, and patients with CJD who received compassionate treatment with doxycycline showed increased survival time compared with historical series. We therefore did a randomised, double-blind study of doxycycline versus placebo in CJD.; […]
Robot services for elderly with cognitive impairment: testing usability of graphical user interfaces
Granata, C.,
Pino, M.,
Legouverneur, G.,
Vidal, J. S.,
Bidaud, P.,
Rigaud, A. S.
Background: Socially assistive robotics for elderly care is a growing field. However, although robotics has the potential to support elderly in daily tasks by offering specific services, the development of usable interfaces is still a challenge. Since several factors such as age or disease-related changes in perceptual or cognitive abilities and familiarity with computer technologies […]
Semantic memory training in Alzheimer’s disease
The purpose of this study was to assess the effects of semantic stimulation of Alzheimer’s patients on semantic memory comparatively to psychological support. We conducted semantic training with two target categories (musical instruments and human actions), because these concepts were massively failed in previous data collected in Alzheimer’s disease. Ten patients (57-78 year old, MMSE […]
Long-term safety of rivastigmine in parkinson disease dementia: an open-label, randomized study
Emre, Murat,
Poewe, Werner,
De Deyn, Peter Paul,
Barone, Paolo,
Kulisevsky, Jaime,
Pourcher, Emmanuelle,
van Laar, Teus,
Storch, Alexander,
Micheli, Federico,
Burn, David,
Durif, Frank,
Pahwa, Rajesh,
Callegari, Francesca,
Tenenbaum, Nadia,
Strohmaier, Christine
Objective: This study investigated the long-term safety of rivastigmine (12 mg/d capsules, 9.5 mg/24 h patch) and effects on motor symptoms in patients with mild-to-moderately severe Parkinson disease dementia.; Methods: This was a 76-week, prospective, open-label, randomized study in patients aged 50 to 85 years. Primary outcomes included incidence of, and discontinuation due to, predefined […]