Kennelly, Sean, Abdullah, Laila, Kenny, Rose Anne, Mathura, Venkat, Luis, Cheryl A., Mouzon, Benoit, Crawford, Fiona, Mullan, Michael, Lawlor, Brian

Background: Evidence suggests that dihydropyridine calcium channel blockers may be useful in preventing and treating Alzheimer’s disease (AD).; Objective: In an open-label trial of safety and tolerability of nilvadipine in patients with AD, we examined cognition and executive function over a short time period to determine an influence of nilvadipine on these outcomes.; Method: We […]

Hampel, Harald, Ewers, Michael, Bürger, Katharina, Annas, Peter, Mörtberg, Anette, Bogstedt, Anna, Frölich, Lutz, Schröder, Johannes, Schönknecht, Peter, Riepe, Matthias W., Kraft, Inga, Gasser, Thomas, Leyhe, Thomas, Möller, Hans-Jürgen, Kurz, Alexander, Basun, Hans

Objective: Lithium, a first-line drug for the treatment of bipolar depression, has recently been shown to regulate glycogen synthase kinase-3 (GSK-3), a kinase that is involved in the phosphorylation of the tau protein. Since hyperphosphorylation of tau is a core pathological feature in Alzheimer’s disease, lithium-induced inhibition of GSK-3 activity may have therapeutic effects in […]

O'Shea, Eamon, Devane, Declan, Murphy, Kathy, Cooney, Adeline, Casey, Dympna, Jordan, Fionnuala, Hunter, Andrew, Murphy, Edel

Background: Current projections indicate that there will be a significant increase in the number of people with dementia in Ireland, from approximately 40,000 at present to 100,000 by 2036. Psychosocial interventions, such as reminiscence, have the potential to improve the quality of life of people with dementia. However, while reminiscence is used widely in dementia […]

O'Caoimh, Rónán, Healy, Liam, Gao, Yang, Svendrovski, Anton, Kerins, David M., Eustace, Joseph, Kehoe, Patrick Gavin, Guyatt, Gordon, Molloy, D. William

Background: Centrally acting angiotensin converting enzyme inhibitors (CACE-Is) are associated with reduced rates of cognitive decline in patients with dementia. CACE-Is may also improve exercise tolerance in functionally impaired older adults with normal cognition, suggesting that CACE-Is may positively influence activities of daily living (ADL) in dementia.; Objective: To compare rates of decline in patients […]

Nolan, John M., Loskutova, Ekaterina, Howard, Alan, Mulcahy, Riona, Moran, Rachel, Stack, Jim, Bolger, Maggie, Coen, Robert F., Dennison, Jessica, Akuffo, Kwadwo Owusu, Owens, Niamh, Power, Rebecca, Thurnham, David, Beatty, Stephen

Background: Patients with Alzheimer’s disease (AD) exhibit significantly less macular pigment (MP) and poorer vision when compared to control subjects. Objective: To investigate supplementation with the macular carotenoids on MP, vision, and cognitive function in patients with AD versus controls. Methods: A randomized, double-blind clinical trial with placebo and active arms. 31 AD patients and […]

Meagher, D. J., Leonard, M., Donnelly, S., Conroy, M., Saunders, J., Trzepacz, P. T.

Purpose: Delirium and dementia have overlapping features that complicate differential diagnosis. Delirium symptoms overshadow dementia symptoms when they co-occur, but delirium phenomenology in comorbid cases has not been compared to both conditions alone.; Methods: Consecutive adults with DSM-IV delirium, dementia, comorbid delirium-dementia and cognitively intact controls were assessed using the Revised Delirium Rating Scale (DRS-R98) […]

Kennelly, S. P., Abdullah, L., Paris, D., Parish, J., Mathura, V., Mullan, M., Crawford, F., Lawlor, B. A., Kenny, R. A.

Background: Nilvadipine may lower rates of conversion from mild-cognitive impairment to Alzheimer’s disease (AD), in hypertensive patients. However, it remains to be determined whether treatment with nilvadipine is safe in AD patients, given the higher incidence of orthostatic hypotension (OH) in this population, who may be more likely to suffer from symptoms associated with the […]