This database contains 89 studies, archived under the term: "Australia"
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The preclinical Alzheimer cognitive composite: Measuring amyloid-related decline
Donohue, Michael C.,
Sperling, Reisa A.,
Salmon, David P.,
Rentz, Dorene M.,
Raman, Rema,
Thomas, Ronald G.,
Weiner, Michael,
Aisen, Paul S
Importance: As Alzheimer disease (AD) research moves to intervene in presymptomatic phases of the disease, we must develop outcome measures sensitive to the earliest disease-related changes. Objective: To demonstrate the feasibility of a cognitive composite outcome for clinically normal elderly participants with evidence of AD pathology using the ADCS Preclinical Alzheimer Cognitive Composite (ADCS-PACC). The […]
The FABS trial: a randomised control trial of the effects of a 6-month physical activity intervention on adherence and long-term physical activity and self-efficacy in older adults with memory complaints
Cox, Kay L.,
Flicker, Leon,
Almeida, Osvaldo P.,
Xiao, Jianguo,
Greenop, Kathryn R.,
Hendriks, Jacqueline,
Phillips, Michael,
Lautenschlager, Nicola T.
Objective: The aim of this study is to assess in older adults with memory complaints, the effects of a 6-month home-based physical activity (PA) intervention on short-term adherence, short and long-term self-efficacy and the predictors of adherence.; Methods: Participants with memory complaints with or without mild cognitive impairment (MCI) were recruited from Perth, Western Australia […]
PerCEN: A cluster randomized controlled trial of person-centered residential care and environment for people with dementia
Chenoweth, Lynn,
Forbes, Ian,
Fleming, Richard,
King, Madeleine T.,
Stein-Parbury, Jane,
Luscombe, Georgina,
Kenny, Patricia,
Jeon, Yun-Hee,
Haas, Marion,
Brodaty, Henry
Background: There is good evidence of the positive effects of person-centered care (PCC) on agitation in dementia. We hypothesized that a person-centered environment (PCE) would achieve similar outcomes by focusing on positive environmental stimuli, and that there would be enhanced outcomes by combining PCC and PCE. Methods: 38 Australian residential aged care homes with scope […]
Successful ingredients in the SMILE study: Resident, staff, and management factors influence the effects of humor therapy in residential aged care
Brodaty, Henry,
Low, Lee-Fay,
Liu, Zhixin,
Fletcher, Jennifer,
Roast, Joel,
Goodenough, Belinda,
Chenoweth, Lynn
Objective: To test the hypothesis that individual and institutional-level factors influence the effects of a humor therapy intervention on aged care residents. Methods: Data were from the humor therapy group of the Sydney Multisite Intervention of LaughterBosses and ElderClowns, or SMILE, study, a single-blind cluster randomized controlled trial of humor therapy conducted over 12 weeks; […]
A cluster-randomised trial of staff education to improve the quality of life of people with dementia living in residential care: the DIRECT study
Beer, Christopher,
Horner, Barbara,
Flicker, Leon,
Scherer, Samuel,
Lautenschlager, Nicola T.,
Bretland, Nick,
Flett, Penelope,
Schaper, Frank,
Almeida, Osvaldo P.
Background: The Dementia In Residential care: EduCation intervention Trial (DIRECT) was conducted to determine if delivery of education designed to meet the perceived need of GPs and care staff improves the quality of life of participants with dementia living in residential care.; Methodology/principal Findings: This cluster-randomised controlled trial was conducted in 39 residential aged care […]
Prediction of amyloid-β pathology in amnestic mild cognitive impairment with neuropsychological tests
Bahar-Fuchs, Alex,
Villemagne, Victor,
Ong, Kevin,
Chetélat, Gaël,
Lamb, Fiona,
Reininger, Cornelia B.,
Woodward, Michael,
Rowe, Christopher C.
Assessment of disease biomarkers, particularly the in vivo assessment of amyloid-β (Aβ) burden with positron emission tomography (PET), is gradually becoming central to the diagnosis of mild cognitive impairment (MCI) due to Alzheimer’s disease (AD). However, the incorporation of biomarker evidence to the diagnostic process is currently restricted mainly to research settings. The identification of […]
Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: analysis of data from the ONTARGET and TRANSCEND studies
Anderson, Craig,
Teo, Koon,
Gao, Peggy,
Arima, Hisatomi,
Dans, Antonio,
Unger, Thomas,
Commerford, Patrick,
Dyal, Leanne,
Schumacher, Helmut,
Pogue, Janice,
Paolasso, Ernesto,
Holwerda, Nicolaas,
Chazova, Irina,
Binbrek, Azan,
Young, James,
Yusuf, Salim
Background: cardiovascular risk factors are associated with dementia and cognitive decline. We investigated the effects of renin-angiotensin system blockade on cognitive function in patients aged 55 years and older with established atherosclerotic cardiovascular disease or diabetes with end-organ damage in two clinical trials.; Methods: in the main study, ONTARGET, a double-blind, double-dummy, randomised controlled trial, […]