Background: Evidence from pilot trials suggests that structured learning techniques may have positive effects on the performance of cognitive tasks, movement sequences or skills in patients with Alzheimer’s disease. The purpose of this trial is to evaluate whether the usual method of learning by trial and error or the method of errorless learning demonstrate better […]
This paper summarises the methods and results of a seven-centre, single-blind, parallel group, actively controlled randomised trial evaluating the effectiveness of a Dutch 10-session community occupational therapy programme for patients with mild to moderate Alzheimer’s disease in German routine healthcare. Methodological aspects for future research on complex psychosocial interventions are discussed. (As supplied by publisher). […]
Background: The ARGO study was a phase II, double-blind, placebo controlled, four parallel arm trial of tideglusib in Alzheimer’s disease (AD). Objective: To prove the clinical efficacy of an inhibitor of glycogen synthase kinase-3 (GSK-3), in AD. Methods: Mild to moderate (Mini-Mental State Examination (MMSE) score, 14–26) AD patients on cholinesterase inhibitor and/or memantine treatment […]