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Vascular care in patients with Alzheimer’s disease with cerebrovascular lesions-a randomized clinical trial


Richard, Edo, Kuiper, Roy, Dijkgraaf, Marcel G. W., van Gool, Willem A.


Journal Of The American Geriatrics Society, Volume: 57, No.: 5, Pages.: 797-805

Year of Publication



Objectives: To investigate whether vascular care slows dementia progression in patients with Alzheimer’s disease with cerebrovascular lesions on neuroimaging.; Design: Multicenter randomized controlled clinical trial with 2-year follow-up.; Setting: Neurological and geriatric outpatient clinics in 10 Dutch hospitals: three academic, five teaching, and two midsize community hospitals.; Participants: One hundred thirty community-dwelling patients with mild dementia fulfilling clinical criteria for Alzheimer’s disease with cerebrovascular lesions on neuroimaging.; Intervention: Patients randomized to vascular care were treated according to strict guidelines for hypercholesterolemia and hypertension. Acetylsalicylic acid, folic acid, and pyridoxine were prescribed. During visits every 3 months special attention was paid to smoking cessation, losing weight, and stimulating physical exercise.; Measurements: Primary outcome was disability, measured according to the Interview for Deterioration in Daily activities in Dementia (IDDD). Secondary outcomes were changes on the Mini-Mental State Examination (MMSE), the Revised Memory and Behavioural Problems Checklist (RMBPC), a composite measure of “poor outcome” (death, institutionalization, or severe clinical decline), and costs.; Results: Patients in the vascular and standard care condition declined equally on the IDDD (13.7 vs 11.0 points; difference 2.7, 95% confidence interval = -3.1-8.6). There was no treatment effect on the MMSE or RMBPC. There were no differences in institutionalization rate, “poor outcome” (41.4% vs 35.4%, P=.50), or costs. In the intervention group, there were three intracerebral hemorrhages and one gastrointestinal hemorrhage, versus none in the control group.; Conclusion: Multicomponent vascular care, combining pharmacological and nonpharmacological interventions, does not slow decline in patients with Alzheimer’s disease with cerebrovascular lesions.;


acid, activities of daily living, aged, alzheimer disease, aspirin, cerebrovascular disorders, diagnosis, diet reducing, disease progression, drug therapy, epidemiology, exercise, female, folic acid, geriatric assessment, humans, linear models, male, netherlands, pyridoxine, smoking cessation, therapeutic use, treatment outcome

Countries of Study


Types of Dementia

Alzheimer’s Disease

Types of Study

Before and After Study

Type of Outcomes

ADLs/IADLs, Behaviour, Carer Burden (instruments measuring burden), Cognition, Service use or cost reductions (incl. hospital use reduction, care home admission delay)


Hospital Outpatient Care

Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions