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Utilisation of atypical antipsychotic drugs in institutionalised elderly persons and prevalence of metabolic alterations


Martínez Romero, G., Peris Martí, J.F., Gomar Fayos, J., Navarro Gosalbez, M., Quintana Vargas, I., Muelas Tirado, J.


Farmacia Hospitalaria: Órgano Oficial De Expresión Científica De La Sociedad Española De Farmacia Hospitalaria, Volume: 34, No.: 3, Pages.: 139-147

Year of Publication



Objectives: Describe and evaluate atypical antipsychotics utilisation on the institutionalized elderly population of the Valencian Community and prevalence of associated metabolic alterations.; Material and Methods: Multicentre transversal descriptive study on medication utilisation and prevalence case-control of alterations of glycaemia, cholesterol and triglycerides. The statistical analysis of metabolic alterations is performed from the difference in prevalence and its statistical signification between the control group and the study group.; Results: 681 patients were included (study group, 344; control group, 337) from 20 social-health-care centres. 18.5% of the institutionalised patients are being treated with atypical antipsychotics. The most frequent diagnoses are: behavioural alterations associated with dementia (63.6%) and schizophrenia (18.4%). Risperidone is the most frequently used antipsychotic (66.0%). For all the drugs in general the doses used adjust to those recommended for elderly patients. The prevalence of alterations in glycaemia, cholesterol and triglycerides metabolism in the group under study is 23.96%, 34.83%, and 26.29%, respectively, with no statistically significant differences against the control group. The analysis by type of drug did not show significant differences.; Conclusions: The results obtained show that utilisation of atypical antipsychotics in elderly patients complies with the established general recommendations. The doses used in elderly patients with behavioural alterations associated with dementia, mostly treated with risperidone, do not have a significant impact over prevalence increase of metabolic alterations.; Copyright © 2008 SEFH. Published by Elsevier Espana. All rights reserved.

Bibtex Citation

@article{Mart_nez_Romero_2010, doi = {10.1016/j.farma.2009.10.010}, url = {}, year = 2010, month = {may}, publisher = {Elsevier {BV}}, volume = {34}, number = {3}, pages = {139--147}, author = {G. Mart{'{i}}nez Romero and J.F. Peris Mart{'{i}} and J. Gomar Fayos and M. Navarro Gosalbez and I. Quintana Vargas and J. Muelas Tirado}, title = {Utilizaci{'{o}}n de f{'{a}}rmacos antipsic{'{o}}ticos at{'{i}}picos en ancianos institucionalizados y prevalencia de alteraciones metab{'{o}}licas}, journal = {Farmacia Hospitalaria} }


adverse effects, aged, aged, 80 and over, antipsychotic agents, chemically induced, comorbidity, dementia, drug therapy, epidemiology, etiology, female, glucose intolerance, humans, hypercholesterolemia, hypertriglyceridemia, institutionalization, male, mental disorders, middle aged, polypharmacy, prevalence, psychology, risperidone, schizophrenia, spain, therapeutic use

Countries of Study


Types of Dementia

Dementia (general / unspecified)

Types of Study

Case Control Study

Type of Outcomes

Prevention and/or management of co-morbidities, Service use or cost reductions (incl. hospital use reduction, care home admission delay)

Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions

Antipsychotics and antidepressants