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Testosterone effect on brain metabolism in elderly patients with Alzheimer’s disease: comparing two cases at different disease stages


Tan, R. S.


Aging Clinical And Experimental Research, Volume: 25, No.: 3, Pages.: 343-347

Year of Publication



Objective: To describe the effect of testosterone replacement therapy (TRT) on the brain activity of two demented, hypogonadal male patients with early and late-stage Alzheimer’s disease (AD), respectively.; Methods: We describe the clinical and positron emission tomography (PET) findings for two individuals, one with early stage and the other with late-stage Alzheimer’s disease, before and after treatment with a topical testosterone gel. Both patients were hypogonadal at baseline. We assessed cerebral glucose metabolism (CGM) via (18)F-fluorodeoxyglucose (FDG)-positron emission tomography (PET). We investigated whether there are testosterone-susceptible areas within cerebral structures in patients with Alzheimer’s disease.; Results: Under testosterone replacement therapy, changes in cerebral glucose metabolism were observed in both patients. Improvement in glucose uptake was observed most consistently in the parietal lobe and brainstem; decreased glucose metabolism was observed in the temporal lobe, the limbic system and the insula for these two subjects.; Discussion: These case reports demonstrate the potential for PET scanning to detect changes in cerebral glucose metabolism in hypogonadal men with Alzheimer’s disease who are treated with testosterone. Further study will be needed to investigate the consistency and significance of these changes in terms of magnitude and brain region, and the correlation with functional changes.;

Bibtex Citation

@article{Tan_2013, doi = {10.1007/s40520-013-0049-2}, url = {}, year = 2013, month = {may}, publisher = {Springer Science $mathplus$ Business Media}, volume = {25}, number = {3}, pages = {343--347}, author = {R. S. Tan}, title = {Testosterone effect on brain metabolism in elderly patients with Alzheimer's disease: comparing two cases at different disease stages}, journal = {Aging Clinical and Experimental Research} }


aged, 80 and over, aging, alzheimer disease, brain, cerebral, changes, disease progression, drug therapy, glucose, hormone replacement therapy, humans, hypogonadism, in, male, metabolism, pharmacology, radionuclide imaging, replacement, testosterone, therapeutic use, therapy, treatment outcome

Countries of Study


Types of Dementia

Alzheimer’s Disease

Types of Study

Before and After Study

Type of Outcomes


Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions