This site uses cookies to measure how you use the website so it can be updated and improved based on your needs and also uses cookies to help remember the notifications you’ve seen, like this one, so that we don’t show them to you again. If you could also tell us a little bit about yourself, this information will help us understand how we can support you better and make this site even easier for you to use and navigate.

Risk of cerebrovascular accident associated with use of antipsychotics: population-based case-control study


Laredo, Leonor, Vargas, Emilio, Blasco, Antonio Javier, Aguilar, Maria Dolores, Moreno, Alfonso, Portolés, Antonio


Journal Of The American Geriatrics Society, Volume: 59, No.: 7, Pages.: 1182-1187

Year of Publication



Objectives: To explore the association between use of antipsychotics and risk of cerebrovascular accident (CVA) in individuals with dementia aged 65 and older.; Design: Population-based case-control study.; Setting: UK-based electronic primary care records in the General Practice Research Database (GPRD).; Participants: Individuals with dementia aged 65 and older registered in the database between January 1, 1995, and June 22, 2007.; Measurements: Odds ratio (OR) of CVA in users versus nonusers of antipsychotics (typical or atypical) and in users of typical versus atypical antipsychotics. Multivariate analyses were performed using logistic regression models to adjust for potential confounders: demographic variables, comorbidity, and concomitant treatments.; Results: After adjusting for confounding variables, the OR of CVA associated with use of only typical antipsychotics versus no antipsychotics in individuals with dementia aged 65 and older was 1.16 (95% confidence interval (CI)=1.07-1.27) and for use of only atypical antipsychotics versus no antipsychotics was 0.62 (95% CI=0.53-0.72). In the comparison of typical versus atypical antipsychotics, the OR was 1.83 (95% CI=1.57-2.14).; Conclusion: No reasons were found to question the cerebrovascular safety of atypical antipsychotics in older adults with dementia. The typical antipsychotics appear to be associated with a higher risk of CVA, although the risk disappears after use is discontinued.; © 2011, Copyright the Authors. Journal compilation © 2011, The American Geriatrics Society.

Bibtex Citation

@article{Laredo_2011, doi = {10.1111/j.1532-5415.2011.03479.x}, url = {}, year = 2011, month = {jun}, publisher = {Wiley-Blackwell}, volume = {59}, number = {7}, pages = {1182--1187}, author = {Leonor Laredo and Emilio Vargas and Antonio Javier Blasco and Maria Dolores Aguilar and Alfonso Moreno and Antonio Portol{'{e}}s}, title = {Risk of Cerebrovascular Accident Associated with Use of Antipsychotics: Population-Based Case-Control Study}, journal = {Journal of the American Geriatrics Society} }


adverse, adverse effects, aged, aged, 80 and over, and, antipsychotic agents, antipsychotics, atypical, chemically induced, dementia, drug therapy, events, female, humans, logistic models, male, odds ratio, stroke, typical

Countries of Study


Types of Dementia

Dementia (general / unspecified)

Types of Study

Case Control Study

Type of Outcomes

Other, Prevention and/or management of co-morbidities

Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions

Antipsychotics and antidepressants