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Quality of life and the effect of memantine in dementia with lewy bodies and Parkinson’s disease dementia


Larsson, Victoria, Engedal, Knut, Aarsland, Dag, Wattmo, Carina, Minthon, Lennart, Londos, Elisabet


Dementia And Geriatric Cognitive Disorders, Volume: 32, No.: 4, Pages.: 227-234

Year of Publication



Aim: To investigate quality of life (QOL) and the effect of memantine treatment in patients with Lewy body dementias.; Methods: A secondary analysis of a randomized controlled study in 70 patients with Parkinson’s disease dementia (PDD) or dementia with Lewy bodies (DLB) over 24 weeks using caregiver-rated QOL-Alzheimer’s disease (AD) in domains according to the WHO’s classification of health.; Results: Baseline QOL shows lower ratings for body functions over environmental factors in DLB/PDD. Treatment with memantine significantly improves life as a whole compared to placebo and improves total QOL, body function and structure.; Conclusion: This study shows that memantine improves QOL in Lewy body dementias. We also demonstrate important QOL patterns which can be used in clinical practice.; Copyright © 2011 S. Karger AG, Basel.

Bibtex Citation

@article{Larsson_2011, doi = {10.1159/000334523}, url = {}, year = 2011, publisher = {S. Karger {AG}}, volume = {32}, number = {4}, pages = {227--234}, author = {Victoria Larsson and Knut Engedal and Dag Aarsland and Carina Wattmo and Lennart Minthon and Elisabet Londos}, title = {Quality of Life and the Effect of Memantine in Dementia with Lewy Bodies and Parkinson's Disease Dementia}, journal = {Dementia and Geriatric Cognitive Disorders} }


administration & dosage, aged, antiparkinson agents, antipsychotic agents, complications, dementia, diagnostic and statistical manual of mental disorders, double-blind method, drug therapy, etiology, factor analysis statistical, female, humans, levodopa, lewy body disease, male, memantine, neuropsychological tests, parkinson disease, psychology, quality of life, therapeutic use, treatment outcome

Countries of Study


Types of Dementia

Lewy-Body, Parkinson’s Dementia

Types of Study

Randomised Controlled Trial

Type of Outcomes

Quality of Life of Person With Dementia

Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions

Anti-Alzheimer medications, e.g.: donezepil, galantamine, rivastigmine, memantime