This site uses cookies to measure how you use the website so it can be updated and improved based on your needs and also uses cookies to help remember the notifications you’ve seen, like this one, so that we don’t show them to you again. If you could also tell us a little bit about yourself, this information will help us understand how we can support you better and make this site even easier for you to use and navigate.

Preserving cognition, quality of life, physical health and functional ability in Alzheimer’s disease: the effect of physical exercise (ADEX trial): rationale and design


Hoffmann, Kristine, Frederiksen, Kristian S., Sobol, Nanna Aue, Beyer, Nina, Vogel, Asmus, Simonsen, Anja Hviid, Johannsen, Peter, Lolk, Annette, Terkelsen, Ole, Cotman, Carl W., Hasselbalch, Steen G., Waldemar, Gunhild


Neuroepidemiology, Volume: 41, No.: 3-4, Pages.: 198-207

Year of Publication



Background: Exercise is hypothesized to improve cognition, physical performance, functional ability and quality of life, but evidence is scarce. Previous studies were of short duration, often underpowered and involving home-based light exercise programs in patients with undefined dementia. The aim of the ADEX (‘Preserving Cognition, Quality of Life, Physical Health and Functional Ability in Alzheimer’s Disease: the Effect of Physical Exercise’) trial is to establish whether aerobic exercise is effective in improving cognition as well as in reducing the prevalence of psychiatric symptoms among patients with Alzheimer’s disease (AD).; Methods: The ADEX study is a multicenter, single-blind, randomized trial with two arms: an intervention group attending 16 weeks of continuously supervised moderate-to-high intensity aerobic exercise and a control group receiving usual care. We plan to recruit 192 patients with mild AD. The primary outcome measure is change from baseline in cognitive performance at 16 weeks (as measured by the Symbol Digit Modalities test).; Conclusions: To our knowledge this is the first large-scale controlled study to investigate the effects of supervised moderate aerobic exercise on cognition in patients with AD. Recruitment began in January 2012 and results are expected to be available in 2014. We summarize the methodological challenges we and other studies have faced in this type of complex multicenter intervention with unique challenges to study design.; © 2013 S. Karger AG, Basel.

Bibtex Citation

@article{Hoffmann_2013, doi = {10.1159/000354632}, url = {}, year = 2013, publisher = {S. Karger {AG}}, volume = {41}, number = {3-4}, pages = {198--207}, author = {Kristine Hoffmann and Kristian S. Frederiksen and Nanna Aue Sobol and Nina Beyer and Asmus Vogel and Anja Hviid Simonsen and Peter Johannsen and Annette Lolk and Ole Terkelsen and Carl W. Cotman and Steen G. Hasselbalch and Gunhild Waldemar}, title = {Preserving Cognition, Quality of Life, Physical Health and Functional Ability in Alzheimer{textquotesingle}s Disease: The Effect of Physical Exercise ({ADEX} Trial): Rationale and Design}, journal = {Neuroepidemiology} }


alzheimer disease, cognition, exercise therapy, humans, methods, quality of life, randomized controlled trials as topic, therapy

Countries of Study


Types of Dementia

Alzheimer’s Disease

Types of Study

Randomised Controlled Trial

Type of Outcomes



Hospital Outpatient Care

Type of Interventions

Non-pharmacological Treatment

Non-Pharmaceutical Interventions

Exercise (inc. dancing)