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Perseverative errors on the Wisconsin Card Sorting Test and brain perfusion imaging in mild Alzheimer’s disease

Authors

Terada, Seishi, Sato, Shuhei, Honda, Hajime, Kishimoto, Yuki, Takeda, Naoya, Oshima, Etsuko, Yokota, Osamu, Uchitomi, Yosuke

Journal

International Psychogeriatrics / IPA, Volume: 23, No.: 10, Pages.: 1552-1559

Year of Publication

2011

Abstract

Background: The Wisconsin Card Sorting Test (WCST) has long been used to investigate deficits in executive function in humans. The majority of studies investigating deficient WCST performance focused on the number of categories achieved (CA) and the number of perseverative errors of the Nelson type (PEN). However, there is insufficient evidence that these two measures reflect the same neural deficits.; Methods: Twenty AD patients with high PEN scores, and 20 age- and sex-matched AD patients with low PEN scores were selected. All 40 subjects underwent brain SPECT, and the SPECT images were analyzed by Statistical Parametric Mapping.; Results: No significant differences were found between high and low PEN score groups with respect to years of education, Addenbrooke’s Cognitive Examination scores, and Mini-Mental State Examination scores. However, higher z scores for hypoperfusion in the bilateral rectal and orbital gyri were observed in the high PEN score group compared with the low PEN score group.; Conclusions: Our results suggest that functional activity of the bilateral rectal and orbital gyri is closely related to PEN scores on a modified WCST (mWCST). The PEN score on a mWCST might be a promising index of dysfunction of the orbitofrontal area among patients with mild AD.;

Bibtex Citation

@article{Terada_2011, doi = {10.1017/s1041610211001463}, url = {http://dx.doi.org/10.1017/s1041610211001463}, year = 2011, month = {aug}, publisher = {Cambridge University Press ({CUP})}, volume = {23}, number = {10}, pages = {1552--1559}, author = {Seishi Terada and Shuhei Sato and Hajime Honda and Yuki Kishimoto and Naoya Takeda and Etsuko Oshima and Osamu Yokota and Yosuke Uchitomi}, title = {Perseverative errors on the Wisconsin Card Sorting Test and brain perfusion imaging in mild Alzheimer{textquotesingle}s disease}, journal = {Int. Psychogeriatr.} }

Keywords

aged, aged, 80 and over, alzheimer disease, brain, cerebrovascular circulation, diagnosis, executive function, female, humans, male, neuropsychological tests, psychology, radionuclide imaging, severity of illness index, standards

Countries of Study

Japan

Types of Dementia

Alzheimer’s Disease

Types of Study

Instrument development and testing (cross walking of measures, etc.), Non randomised controlled trial

Type of Outcomes

Cognition, Other

Type of Interventions

Diagnostic Target Identification

Diagnostic Targets

Cognition testing (inc. task driven tests such as clock drawing)