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Patterns of cognitive decline, conversion rates, and predictive validity for 3 models of MCI

Authors

Ritchie, L. J., Tuokko, H.

Journal

American Journal Of Alzheimer's Disease And Other Dementias, Volume: 25, No.: 7, Pages.: 592-603

Year of Publication

2010

Abstract

Our objective was to compare the predictive ability of different models of mild cognitive impairment (MCI) as a marker of incipient dementia in a longitudinal population-based Canadian sample. We examined the use of existing, well-documented MCI criteria using data from persons who underwent a clinical examination in the second wave of the Canadian Study of Health and Aging (CSHA). Demographic characteristics, average neuropsychological test performance, and sample frequencies and conversion rates were calculated for each classification. Receiver operating characteristic (ROC) analyses were employed to assess the predictive power of each cognitive classification. The highest sample frequencies and conversion rates were associated with case definitions of multiple-domain MCI. The only diagnostic criteria to significantly predict dementia 5 years later was the cognitive impairment no dementia (CIND)-2 case definition. More restrictive MCI case definitions fail to address the varying temporal increases in decline across different cognitive domains in the progression from normal cognitive functioning and dementia.;

Bibtex Citation

@article{Ritchie_2010, doi = {10.1177/1533317510382286}, url = {http://dx.doi.org/10.1177/1533317510382286}, year = 2010, month = {sep}, publisher = {{SAGE} Publications}, volume = {25}, number = {7}, pages = {592--603}, author = {L. J. Ritchie and H. Tuokko}, title = {Patterns of Cognitive Decline, Conversion Rates, and Predictive Validity for 3 Models of {MCI}}, journal = {American Journal of Alzheimer{textquotesingle}s Disease and Other Dementias} }

Keywords

activities of daily living, aged, aged, 80 and over, algorithms, canada, classification, cognition disorders, dementia, diagnosis, epidemiology, female, humans, longitudinal studies, male, memory disorders, memory longterm, models, neuropsychological tests, prediction, predictive value of tests, prevalence, risk, risk factors, severity of illness index, standards, statistics & numerical data, unspecified

Countries of Study

Canada

Types of Dementia

Mild Cognitive Impairment (MCI)

Types of Study

Epidemiological

Type of Outcomes

Cognition, Other

Type of Interventions

Diagnostic Target Identification

Diagnostic Targets

Cognition testing (inc. task driven tests such as clock drawing), Other