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Montreal cognitive assessment performance in patients with Parkinson’s disease with “normal” global cognition according to mini-mental state examination score


Nazem, Sarra, Siderowf, Andrew D., Duda, John E., Ten Have, Tom, Colcher, Amy, Horn, Stacy S., Moberg, Paul J., Wilkinson, Jayne R., Hurtig, Howard I., Stern, Matthew B., Weintraub, Daniel


Journal Of The American Geriatrics Society, Volume: 57, No.: 2, Pages.: 304-308

Year of Publication



Objectives: To examine Montreal Cognitive Assessment (MoCA) performance in patients with Parkinson’s disease (PD) with “normal” global cognition according to Mini-Mental State Examination (MMSE) score.; Design: A cross-sectional comparison of the MoCA and the MMSE.; Setting: Two movement disorders centers at the University of Pennsylvania and the Philadelphia Veterans Affairs Medical Center.; Participants: A convenience sample of 131 patients with idiopathic PD who were screened for cognitive and psychiatric complications.; Measurements: Subjects were administered the MoCA and MMSE, and only subjects defined as having a normal age- and education-adjusted MMSE score were included in the analyses (N=100). As previously recommended in patients without PD, a MoCA score less than 26 was used to indicate the presence of at least mild cognitive impairment (MCI).; Results: Mean MMSE and MoCA scores+/-standard deviation were 28.8+/-1.1 and 24.9+/-3.1, respectively. More than half (52.0%) of subjects with normal MMSE scores had cognitive impairment according to their MoCA score. Impairments were seen in numerous cognitive domains, including memory, visuospatial and executive abilities, attention, and language. Predictors of cognitive impairment on the MoCA using univariate analyses were male sex, older age, lower educational level, and greater disease severity; older age was the only predictor in a multivariate model.; Conclusion: Approximately half of patients with PD with a normal MMSE score have cognitive impairment based on the recommended MoCA cutoff score. These results suggest that MCI is common in PD and that the MoCA is a more sensitive instrument than the MMSE for its detection.;

Bibtex Citation

@article{Nazem_2009, doi = {10.1111/j.1532-5415.2008.02096.x}, url = {}, year = 2009, month = {feb}, publisher = {Wiley-Blackwell}, volume = {57}, number = {2}, pages = {304--308}, author = {Sarra Nazem and Andrew D. Siderowf and John E. Duda and Tom Ten Have and Amy Colcher and Stacy S. Horn and Paul J. Moberg and Jayne R. Wilkinson and Howard I. Hurtig and Matthew B. Stern and Daniel Weintraub}, title = {Montreal Cognitive Assessment Performance in Patients with Parkinson{textquotesingle}s Disease with {^{a}}€œNormal{^{a}}€ Global Cognition According to Mini-Mental State Examination Score}, journal = {Journal of the American Geriatrics Society} }


age factors, aged, cognition, cognition disorders, complications, etiology, female, humans, male, mental status schedule, neuropsychological tests, parkinson disease, psychology

Countries of Study


Types of Dementia

Mild Cognitive Impairment (MCI)

Types of Study

Instrument development and testing (cross walking of measures, etc.)


Primary Care

Type of Interventions

Diagnostic Target Identification

Diagnostic Targets

Cognition testing (inc. task driven tests such as clock drawing)