This site uses cookies to measure how you use the website so it can be updated and improved based on your needs and also uses cookies to help remember the notifications you’ve seen, like this one, so that we don’t show them to you again. If you could also tell us a little bit about yourself, this information will help us understand how we can support you better and make this site even easier for you to use and navigate.

Midlife cardiovascular risk factors and late cognitive impairment

Authors

Virta, Jyri J., Heikkilä, Kauko, Perola, Markus, Koskenvuo, Markku, Räihä, Ismo, Rinne, Juha O., Kaprio, Jaakko

Journal

European Journal Of Epidemiology, Volume: 28, No.: 5, Pages.: 405-416

Year of Publication

2013

Abstract

Cardiovascular risk factors increase the risk of dementia in later life. The aims of the current study were to assess the effect of multiple midlife cardiovascular risk factors on the risk of cognitive impairment in later life, and to assess the validity of the previously suggested CAIDE Study risk score predicting dementia risk 20 years later. A total of 2,165 Finnish twins were followed and at the end of the follow-up their cognitive status was assessed with a validated telephone interview. The assessment of the risk factors at baseline was based on a self-report questionnaire. Relative risk ratios (RR) were calculated and receiver operating characteristic analyses performed. Midlife obesity (RR 2.42, 95 % CI 1.47-3.98), hypertension (RR 1.38, 95 % CI 1.01-1.88) and low leisure time physical activity (RR 2.52, 95 % CI 1.10-5.76) increased the risk of cognitive impairment after a mean follow-up of 22.6 ± 2.3 years. Hypercholesterolemia did not significantly increase the risk (RR 1.52, 95 % CI 0.92-2.51). Overweight individuals who gained more than 10 % weight between 1981 and 1990 had an increased risk of cognitive impairment (RR 4.27, 95 % CI 1.62-11.2). The CAIDE Study risk score combining various individual risk factors had an area-under-curve of 0.74 (95 % CI 0.69-0.79, n = 591), and there was a strong association between an increasing risk score and the risk of cognitive impairment. The results indicate that multiple midlife cardiovascular risk factors increase the risk of cognitive impairment in later life. Also, a risk score including easily measurable midlife factors predicts an individual’s cognitive impairment risk well.;

Bibtex Citation

@article{Virta_2013, doi = {10.1007/s10654-013-9794-y}, url = {http://dx.doi.org/10.1007/s10654-013-9794-y}, year = 2013, month = {mar}, publisher = {Springer Science $mathplus$ Business Media}, volume = {28}, number = {5}, pages = {405--416}, author = {Jyri J. Virta and Kauko Heikkilä and Markus Perola and Markku Koskenvuo and Ismo Räihä and Juha O. Rinne and Jaakko Kaprio}, title = {Midlife cardiovascular risk factors and late cognitive impairment}, journal = {Eur J Epidemiol} }

Keywords

aged, aging, apolipoprotein e4, blood, body mass index, cardiovascular diseases, cognition disorders, complications, dementia, epidemiology, etiology, exercise, female, finland, genetics, genotype, humans, interviews as topic, male, middle aged, neuropsychological tests, obesity, predictive value of tests, psychology, questionnaires, regression analysis, reproducibility of results, risk assessment, risk factors, socioeconomic factors, twins monozygotic

Countries of Study

Finland

Types of Dementia

Dementia (general / unspecified)

Types of Study

Cohort Study, Epidemiological

Type of Outcomes

Risk reduction (of dementia and co-morbidities)

Settings

Community

Type of Interventions

Risk Factor Modification

Risk Factor Modifications

General population health promotion