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Informant-reported cognitive symptoms that predict amnestic mild cognitive impairment


Malek-Ahmadi, Michael, Davis, Kathryn, Belden, Christine M, Jacobson, Sandra, Sabbagh, Marwan N.


BMC Geriatrics, Volume: 12, Pages.: 3-3

Year of Publication



Background: Differentiating amnestic mild cognitive impairment (aMCI) from normal cognition is difficult in clinical settings. Self-reported and informant-reported memory complaints occur often in both clinical groups, which then necessitates the use of a comprehensive neuropsychological examination to make a differential diagnosis. However, the ability to identify cognitive symptoms that are predictive of aMCI through informant-based information may provide some clinical utility in accurately identifying individuals who are at risk for developing Alzheimer’s disease (AD).; Methods: The current study utilized a case-control design using data from an ongoing validation study of the Alzheimer’s Questionnaire (AQ), an informant-based dementia assessment. Data from 51 cognitively normal (CN) individuals participating in a brain donation program and 47 aMCI individuals seen in a neurology practice at the same institute were analyzed to determine which AQ items differentiated aMCI from CN individuals.; Results: Forward stepwise multiple logistic regression analysis which controlled for age and education showed that 4 AQ items were strong indicators of aMCI which included: repetition of statements and/or questions [OR 13.20 (3.02, 57.66)]; trouble knowing the day, date, month, year, and time [OR 17.97 (2.63, 122.77)]; difficulty managing finances [OR 11.60 (2.10, 63.99)]; and decreased sense of direction [OR 5.84 (1.09, 31.30)].; Conclusions: Overall, these data indicate that certain informant-reported cognitive symptoms may help clinicians differentiate individuals with aMCI from those with normal cognition. Items pertaining to repetition of statements, orientation, ability to manage finances, and visuospatial disorientation had high discriminatory power.;

Bibtex Citation

@article{Malek_Ahmadi_2012, doi = {10.1186/1471-2318-12-3}, url = {}, year = 2012, month = {feb}, publisher = {Springer Nature}, volume = {12}, number = {1}, author = {Michael Malek-Ahmadi and Kathryn Davis and Christine M Belden and Sandra Jacobson and Marwan N Sabbagh}, title = {Informant-reported cognitive symptoms that predict amnestic mild cognitive impairment}, journal = {{BMC} Geriatr} }


aged, aged, 80 and over, amnesia, diagnosis, female, humans, male, mild cognitive impairment, neuropsychological tests, predictive value of tests, psychology, questionnaires, self report, standards

Countries of Study


Types of Dementia

Mild Cognitive Impairment (MCI)

Types of Study

Case Control Study

Type of Interventions

Diagnostic Target Identification

Diagnostic Targets

Cognition testing (inc. task driven tests such as clock drawing)