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Exploring sleep‐related outcomes in patients with mild to moderate Alzheimer’s disease initiating acetylcholinesterase inhibitor therapy: The Morpheus survey


Petiau, Christophe, Onen, Hakki, Delgado, Antonio, Touchon, Jacques


International Journal of Geriatric Psychiatry, Volume: 28, No.: 6, Pages.: 657-659

Year of Publication



Presents a study which aims to explore sleep related outcomes in patients with mild moderate Alzheimer’s disease (AD) initiating acetylcholinesterase inhibitor therapy. This study is a prospective, observational, longitudinal, multicentre survey evaluating sleep quality in AD patients initiating acetylcholinesterase inhibitor (AChEI) treatment. Data for this study were collected at AChEI initiation and after 3 to 6 months follow up and a total of baseline cohort included 950 patients. Results reported that 23% patients of the 746 had impaired sleep quality and at the baseline, 42% of patients exhibited at least one symptom described by the Sleep Disorders Inventory (SDI). This study identified factors associated with impaired quality of sleep in patients with mild to moderate AD initiating AChEI therapy. In some individuals, improvements in sleep related outcomes may be apparent after starting AChEI treatment, and benefits associated with improving sleep may therefore accrue. (PsycINFO Database Record (c) 2013 APA, all rights reserved)

Bibtex Citation

@article{Petiau_2013, doi = {10.1002/gps.3896}, url = {}, year = 2013, month = {may}, publisher = {Wiley-Blackwell}, volume = {28}, number = {6}, pages = {657--659}, author = {Christophe Petiau and Hakki Onen and Antonio Delgado and Jacques Touchon}, title = {Exploring sleep-related outcomes in patients with mild to moderate Alzheimer{textquotesingle}s disease initiating acetylcholinesterase inhibitor therapy: the Morpheus survey}, journal = {Int J Geriatr Psychiatry} }


acetylcholinesterase, acetylcholinesterase inhibitor, acetylcholinesterase inhibitor therapy, alzheimer’s disease, cholinesterase inhibitors, drug therapy, inhibitor, pathological changes, sleep, sleep related outcomes

Countries of Study


Types of Dementia

Alzheimer’s Disease

Types of Study


Type of Outcomes


Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions

Anti-Alzheimer medications, e.g.: donezepil, galantamine, rivastigmine, memantime