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Effect of second-generation antipsychotics on caregiver burden in Alzheimer’s disease


Mohamed, Somaia, Rosenheck, Robert, Lyketsos, Constantine G., Kaczynski, Richard, Sultzer, David L., Schneider, Lon S.


The Journal Of Clinical Psychiatry, Volume: 73, No.: 1, Pages.: 121-128

Year of Publication



Background: Alzheimer’s disease (AD) imposes a severe burden upon patients and their caregivers. Severity of psychiatric symptoms and behavioral disturbances is an important determinant of caregivers’ experience of burden. These symptoms may be improved with atypical antipsychotic treatment.; Objective: Data from the Clinical Antipsychotic Trials of Intervention Effectiveness-Alzheimer’s Disease (CATIE-AD) trial were used to evaluate the effect of atypical antipsychotics versus placebo on the experiences of caregivers of outpatients with AD.; Method: We compared the effect of atypical antipsychotic drugs (olanzapine, risperidone, or quetiapine-considered together as a group) versus placebo on the experiences of caregivers of AD outpatients (diagnosed according to DSM-IV-TR). We also evaluated whether improvement in patients’ psychiatric and behavioral symptoms mediated the relationship between drug treatment and caregiver burden. The CATIE-AD trial, conducted from April 2001 through November 2004, included outpatients (mean age = 77.9 years [SD = 7.5 years]) in usual care settings and assessed treatment effectiveness over a 9-month period at 42 US sites. In a set of secondary analyses, data from CATIE-AD participants who had at least 1 postbaseline outcome assessment and data from their caregivers were examined in an intention-to-treat (ITT) analysis (N = 361). A phase 1-only analysis was conducted including only observations while patients were receiving the initially randomized drug (N = 153). The Burden Interview, the Beck Depression Inventory, and the Neuropsychiatric Inventory (NPI) Caregiver Distress Scale were used to evaluate caregiver burden.; Results: In both ITT and phase 1-only analyses, caregivers of patients treated with second-generation antipsychotics scored significantly lower than caregivers of patients receiving placebo on both the Burden Interview (P = .0090) and the NPI Caregiver Distress Scale (P = .0209). These differences appeared to have been mediated by lower levels of agitation, hostility, and psychotic distortions.; Conclusion: In AD patients with symptoms of psychosis, agitation, or aggressive behavior, medications can have a small but significant impact on caregiver burden.; © Copyright 2012 Physicians Postgraduate Press, Inc.

Bibtex Citation

@article{Mohamed_2011, doi = {10.4088/jcp.10m06574}, url = {}, year = 2011, month = {sep}, publisher = {Physicians Postgraduate Press, Inc}, volume = {73}, number = {01}, pages = {121--128}, author = {Somaia Mohamed and Robert Rosenheck and Constantine G. Lyketsos and Richard Kaczynski and David L. Sultzer and Lon S. Schneider}, title = {Effect of Second-Generation Antipsychotics on Caregiver Burden in Alzheimer's Disease}, journal = {J. Clin. Psychiatry} }


activities of daily living, aged, alzheimer disease, antipsychotic agents, caregivers, complications, cost of illness, drug therapy, female, humans, male, mental disorders, nursing, olanzapine, or, psychiatric status rating scales, psychology, quality of life, quetiapine, risperidone, statistics & numerical data, therapeutic use

Countries of Study


Types of Dementia

Alzheimer’s Disease

Types of Study

Randomised Controlled Trial

Type of Outcomes

Carer Burden (instruments measuring burden), Carers’ Mental Health

Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions

Antipsychotics and antidepressants