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Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people


DiSilvestro, Robert A., Joseph, Elizabeth, Zhao, Shi, Bomser, Joshua


Nutrition Journal, Volume: 11, Pages.: 79-79

Year of Publication



Background: Curcumin extracts of turmeric are proposed to produce health benefits. To date, human intervention studies have focused mainly on people with existing health problems given high doses of poorly absorbed curcumin. The purpose of the current study was to check whether in healthy people, a low dose of a lipidated curcumin extract could alter wellness-related measures.; Methods: The present study was conducted in healthy middle aged people (40-60 years old) with a low dose of curcumin (80 mg/day) in a lipidated form expected to have good absorption. Subjects were given either curcumin (N = 19) or placebo (N = 19) for 4 wk. Blood and saliva samples were taken before and after the 4 weeks and analyzed for a variety of blood and saliva measures relevant to health promotion.; Results: Curcumin, but not placebo, produced the following statistically significant changes: lowering of plasma triglyceride values, lowering of salivary amylase levels, raising of salivary radical scavenging capacities, raising of plasma catalase activities, lowering of plasma beta amyloid protein concentrations, lowering of plasma sICAM readings, increased plasma myeloperoxidase without increased c-reactive protein levels, increased plasma nitric oxide, and decreased plasma alanine amino transferase activities.; Conclusion: Collectively, these results demonstrate that a low dose of a curcumin-lipid preparation can produce a variety of potentially health promoting effects in healthy middle aged people.;

Bibtex Citation

@article{DiSilvestro_2012, doi = {10.1186/1475-2891-11-79}, url = {}, year = 2012, month = {sep}, publisher = {Springer Nature}, volume = {11}, number = {1}, author = {Robert A DiSilvestro and Elizabeth Joseph and Shi Zhao and Joshua Bomser}, title = {Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people}, journal = {Nutrition Journal} }


administration & dosage, adult, aging, alzheimer disease, amyloid, analysis, antiinflammatory agents nonsteroidal, antioxidants, beta, biological markers, blood, cardiovascular diseases, chemistry, curcuma, curcumin, dietary supplements, epidemiology, female, humans, hypertriglyceridemia, levels, lipids, male, metabolism, middle aged, ohio, plant extracts, plant roots, prevention & control, protein, risk, stress, psychological, therapeutic use

Countries of Study


Types of Study

Randomised Controlled Trial

Type of Outcomes


Type of Interventions

Risk Factor Modification

Risk Factor Modifications

General population health promotion