This site uses cookies to measure how you use the website so it can be updated and improved based on your needs and also uses cookies to help remember the notifications you’ve seen, like this one, so that we don’t show them to you again. If you could also tell us a little bit about yourself, this information will help us understand how we can support you better and make this site even easier for you to use and navigate.

Cognitive training changes hippocampal function in mild cognitive impairment: a pilot study


Rosen, Allyson C., Sugiura, Lisa, Kramer, Joel H., Whitfield-Gabrieli, Susan, Gabrieli, John D.


Journal Of Alzheimer's Disease: JAD, Volume: 26 Suppl 3, Pages.: 349-357

Year of Publication



A randomized pilot experiment examined the neural substrates of response to cognitive training in participants with mild cognitive impairment (MCI). Participants performed exercises previously demonstrated to improve verbal memory and an active control group performed other computer activities. An auditory-verbal fMRI task was conducted before and after the two-month training program. Verbal memory scores improved significantly and left hippocampal activation increased significantly in the experimental group (gains in 5 of 6 participants) relative to the control group (reductions in all 6 participants). Results suggest that the hippocampus in MCI may retain sufficient neuroplasticity to benefit from cognitive training.;


aged, aged, 80 and over, blood, blood supply, brain mapping, cognitive therapy, female, hippocampus, humans, magnetic resonance imaging, male, methods, middle aged, mild cognitive impairment, neuropsychological tests, oxygen, pathology, physiopathology, pilot projects, rehabilitation, treatment outcome

Countries of Study


Types of Dementia

Mild Cognitive Impairment (MCI)

Types of Study

Randomised Controlled Trial

Type of Outcomes


Type of Interventions

Non-pharmacological Treatment

Non-Pharmaceutical Interventions

Adult safeguarding and abuse detection/prevention