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Antihypertensive therapy and cerebral hemodynamics in executive mild cognitive impairment: results of a pilot randomized clinical trial


Hajjar, Ihab, Hart, Meaghan, Chen, Yu-Ling, Mack, Wendy, Novak, Vera, C. Chui, Helena, Lipsitz, Lewis


Journal Of The American Geriatrics Society, Volume: 61, No.: 2, Pages.: 194-201

Year of Publication



Objectives: To compare the effects of three antihypertensive medications on cerebral hemodynamic and cognitive function in hypertensive individuals with executive dysfunction.; Design: Double-blind randomized clinical trial.; Setting: Community.; Participants: Fifty-three individuals aged 60 and older with hypertension and executive dysfunction.; Intervention: Lisinopril, candesartan, or hydrochlorothiazide for 1 year.; Measurements: Cerebral blood flow velocity (BFV; transcranial Doppler ultrasonography during rest, sitting, standing, hypercapnia, and hypocapnia), cognition, and blood pressure were measured at baseline and after 6 and 12 months. Linear mixed models were used to compare the three groups.; Results: Of the 53 participants, 47 had successful insonation (mean age 72; 70% white; 57% women). There was a tendency toward an increase in BFV in the candesartan group and a decrease in the lisinopril and hydrochlorothiazide groups (between-group P = .57) that was significant in those with low BFV at baseline (

Bibtex Citation

@article{Hajjar_2013, doi = {10.1111/jgs.12100}, url = {}, year = 2013, month = {jan}, publisher = {Wiley-Blackwell}, volume = {61}, number = {2}, pages = {194--201}, author = {Ihab Hajjar and Meaghan Hart and Yu-Ling Chen and Wendy Mack and Vera Novak and Helena C. Chui and Lewis Lipsitz}, title = {Antihypertensive Therapy and Cerebral Hemodynamics in Executive Mild Cognitive Impairment: Results of a Pilot Randomized Clinical Trial}, journal = {Journal of the American Geriatrics Society} }


administration & dosage, aged, angiotensin ii type 1 receptor blockers, antihypertensive, benzimidazoles, blood, blood pressure, cerebrovascular circulation, cognition, complications, double-blind method, drug effects, drug therapy, female, flow, humans, hydrochlorothiazide, hypertension, lisinopril, male, medications, middle aged, mild cognitive impairment, or, physiology, physiopathology, pilot projects, pressure, regional blood flow, tetrazoles, treatment outcome, velocity

Countries of Study


Types of Dementia

Mild Cognitive Impairment (MCI)

Types of Study

Randomised Controlled Trial

Type of Outcomes

Cognition, Prevention and/or management of co-morbidities



Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions