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A prospective study of ventriculo-peritoneal shunting for idiopathic normal pressure hydrocephalus


Razay, George, Vreugdenhil, Anthea, Liddell, John


Journal Of Clinical Neuroscience: Official Journal Of The Neurosurgical Society Of Australasia, Volume: 16, No.: 9, Pages.: 1180-1183

Year of Publication



Idiopathic normal pressure hydrocephalus (INPH) is a potentially treatable form of dementia but its diagnosis is difficult and the effectiveness of shunting remains controversial. This study investigates the clinical outcomes of ventriculo-peritoneal shunting in a controlled trial of 33 consecutive patients with INPH. Mean age was 77.2 years (range 58-92 years) and the duration of symptoms was 4.6 years (3 months-14 years). Nineteen patients underwent shunt surgery. At 3-4 months follow-up, patients who had undergone shunt surgery, compared to those who had not (controls), had significantly better global change ratings (median Clinician’s Interview Based Impression of Change with Carer Input rating of 2 [moderately improved] versus 6 [moderately worsened], respectively, p<0.001), had increased Mini Mental State Examination scores by 5 points (p<0.001) and were 6.3s faster on the Timed "up and go" test (p=0.008). We conclude that ventriculo-peritoneal shunting is associated with improved clinical outcomes for patients with INPH.;

Bibtex Citation

@article{Razay_2009, doi = {10.1016/j.jocn.2008.12.007}, url = {}, year = 2009, month = {sep}, publisher = {Elsevier {BV}}, volume = {16}, number = {9}, pages = {1180--1183}, author = {George Razay and Anthea Vreugdenhil and John Liddell}, title = {A prospective study of ventriculo-peritoneal shunting for idiopathic normal pressure hydrocephalus}, journal = {Journal of Clinical Neuroscience} }


adverse effects, aged, aged, 80 and over, complications, female, humans, hydroceaphalus, hydrocephalus, normal pressure, idiopathic, inph, male, middle aged, normal, pressure, prospective studies, shunt, surgery, treatment outcome, ventriculoperitoneal shunt

Countries of Study


Types of Study

Non randomised controlled trial

Type of Outcomes


Type of Interventions

Non-pharmacological Treatment

Non-Pharmaceutical Interventions