Handels, R. L., Joore, M. A., Tran-Duy, A., Wimo, A., Wolfs, C. A., Verhey, F. R., Severens, J. L.

INTRODUCTION: The study aimed to determine the room for improvement of a perfect cerebrospinal fluid (CSF) biomarker and the societal incremental net monetary benefit of CSF in subjects with mild cognitive impairment (MCI) assuming a hypothetical disease-modifying Alzheimer’s disease (AD) treatment. METHODS: A decision model compared current practice to a perfect biomarker and to two […]

Diamond, Keri, Mowszowski, Loren, Cockayne, Nicole, Norrie, Louisa, Paradise, Matthew, Hermens, Daniel F., Lewis, Simon J. G., Hickie, Ian B., Naismith, Sharon L.

Background: With the rise in the ageing population and absence of a cure for dementia, cost-effective prevention strategies for those ‘at risk’ of dementia including those with depression and/or mild cognitive impairment are urgently required. Objective: This study evaluated the efficacy of a multifaceted Healthy Brain Ageing Cognitive Training (HBA-CT) program for older adults ‘at […]

Dubois, Bruno, Zaim, Mohammed, Touchon, Jacques, Vellas, Bruno, Robert, Philippe, Murphy, Michael F., Pujadas-Navinés, Francesc, Rainer, Michael, Soininen, Hilkka, Riordan, Henry J., Kanony-Truc, Claire

New criteria related to prodromal Alzheimer’s disease (AD) have been proposed to overcome the issue of heterogeneity of patients with mild cognitive impairment (MCI) and to better define patients in early stage AD. Only few therapeutic trials, if any, have been reported using this newly defined population. The objective of this study was to assess […]

Howard, Robert, McShane, Rupert, Lindesay, James, Ritchie, Craig, Baldwin, Ashley, Barber, Robert, Burns, Alistair, Dening, Tom, Findlay, David, Holmes, Clive, Hughes, Alan, Jacoby, Robin, Jones, Rob, Jones, Roy, McKeith, Ian, Macharouthu, Ajay, O'Brien, John, Passmore, Peter, Sheehan, Bart, Juszczak, Edmund, Katona, Cornelius, Hills, Robert, Knapp, Martin, Ballard, Clive, Brown, Richard, Banerjee, Sube, Onions, Caroline, Griffin, Mary, Adams, Jessica, Gray, Richard, Johnson, Tony, Bentham, Peter, Phillips, Patrick

Background: Clinical trials have shown the benefits of cholinesterase inhibitors for the treatment of mild-to-moderate Alzheimer’s disease. It is not known whether treatment benefits continue after the progression to moderate-to-severe disease.; Methods: We assigned 295 community-dwelling patients who had been treated with donepezil for at least 3 months and who had moderate or severe Alzheimer’s […]

Cumming, Toby B., Blomstrand, Christian, Bernhardt, Julie, Linden, Thomas

Background: Cognitive impairment is an important but underrecognised consequence of stroke. We investigated whether a subset of items from the NIH Stroke Scale (NIHSS) could yield valid information on cognitive status in a group of stroke patients.; Methods: 149 stroke patients from the Göteborg 70+ Stroke Study were investigated after 18 months. We extracted 4 […]

Gehrman, Philip R., Connor, Donald J., Martin, Jennifer L., Shochat, Tamar, Corey-Bloom, Jody, Ancoli-Israel, Sonia

Objectives: Patients with Alzheimer dementia often display both agitated behavior and poor sleep. Given that the disease is often associated with low endogenous levels of melatonin, exogenous melatonin administration may lead to improvements in sleep and agitation.; Design: Randomized, placebo-controlled study.; Setting: Nursing homes in San Diego, CA, metropolitan area.; Participants: Subjects were patients with […]