Heller, Robert B., Dobbs, Bonnie M., Strain, Laurel A.

The effect of cognitively congruent video programming on attentional engagement, as measured by the average look duration and the proportion of the video viewed, was examined among long-term care facility residents with Alzheimer’s disease. Over a 2-week period, 24 residents viewed 4 cognitively congruent videos and 1 control video (ie, a recorded episode of a […]

Yang, Jin-Chen, Niu, Yu-Qiong, Simon, Christa, Seritan, Andreea L, Chen, Lawrence, Schneider, Andrea, Moghaddam, Shayan T, Hagerman, Paul J, Hagerman, Randi J, Olichney, John M

Older FMR1 premutation carriers may develop fragile X-associated tremor/ataxia syndrome (FXTAS), a neurodegenerative disorder manifesting cognitive deficits that often subsequently progress to dementia. To date, there is no specific treatment available for FXTAS. Studies have demonstrated the premutation-associated overactivation of glutamatergic receptors in neurons. Memantine, a NMDA receptor antagonist approved for treatment of Alzheimer’s disease, […]

Koyama, Alain, Steinman, Michael, Ensrud, Kristine, Hillier, Teresa A., Yaffe, Kristine

Objectives: To determine which older adults tend to receive potentially inappropriate medications (PIMs), how this may differ according to cognitive status, and how the trajectories of PIM use change over time. Design: Ten-year longitudinal cohort study. Setting: Three clinical sites in the United States. Participants: One thousand four hundred eighty-four community-dwelling women aged 75 and […]

Huntington Study Group Reach2HD Investigators,

Background: PBT2 is a metal protein-attenuating compound that might reduce metal-induced aggregation of mutant huntingtin and has prolonged survival in a mouse model of Huntington’s disease. We aimed to assess the safety, tolerability, and efficacy of PBT2 in patients with Huntington’s disease. Methods: In this 26-week, randomised, double-blind, placebo-controlled trial, adults (≥ 25 years old) […]