Wingenfeld, K., Seidl, N., Ammann, A.

Disruptive behavior is an increasing challenge for professional care in nursing homes. It frequently accompanies dementia, which is one of the most common chronic illnesses among the residents. Nursing homes are, therefore, subject to a high accumulation of problems due to behavior with risk potential. However, usual nursing interventions are often limited to restrictions in […]

Heaton, Robert K., Franklin, Donald R., Ellis, Ronald J., McCutchan, J. Allen, Letendre, Scott L., Leblanc, Shannon, Corkran, Stephanie H., Duarte, Nichole A., Clifford, David B., Woods, Steven P., Collier, Ann C., Marra, Christina M., Morgello, Susan, Mindt, Monica Rivera, Taylor, Michael J., Marcotte, Thomas D., Atkinson, J. Hampton, Wolfson, Tanya, Gelman, Benjamin B., McArthur, Justin C., Simpson, David M., Abramson, Ian, Gamst, Anthony, Fennema-Notestine, Christine, Jernigan, Terry L., Wong, Joseph, Grant, Igor

Combination antiretroviral therapy (CART) has greatly reduced medical morbidity and mortality with HIV infection, but high rates of HIV-associated neurocognitive disorders (HAND) continue to be reported. Because large HIV-infected (HIV+) and uninfected (HIV-) groups have not been studied with similar methods in the pre-CART and CART eras, it is unclear whether CART has changed the […]

Zhang, Yu, Tartaglia, Maria Carmela, Schuff, Norbert, Chiang, Gloria C., Ching, Christopher, Rosen, Howard J., Gorno-Tempini, Maria Luisa, Miller, Bruce L., Weiner, Michael W.

Brain magnetic resonance imaging (MRI) studies have demonstrated regional patterns of brain macrostructural atrophy and white matter microstructural alterations separately in the three major subtypes of frontotemporal lobar degeneration (FTLD), which includes behavioral variant frontotemporal dementia (bvFTD), semantic dementia (SD), and progressive nonfluent aphasia (PNFA). This study was to investigate to what extent the pattern […]

Sato, Y., Honda, Y., Iwamoto, J., Amano, N.

Objectives: Minodronate is a nitrogen-containing bisphosphonate that is commercially available for the treatment of osteoporosis in Japan. Preclinical studies demonstrated that minodronate is at least 10 times more potent than alendronate in inhibiting bone resorption in vivo. A high incidence of fractures, particularly of the hip, represents an important problem in Alzheimer disease (AD) patients […]

Hyttinen, Laura, TuulioHenriksson, Annamari, Vuorio, Alpo F., Kuosmanen, Noora, Härkänen, Tommi, Koskinen, Seppo, Strandberg, Timo E.

The cognitive status of aged familial hypercholesterolemia (FH) patients treated with long-term statin therapy was compared with that of population controls. A comprehensive cohort of 43 elderly (age > or = 65 years) patients all with the same FH North Karelia mutation living in North Karelia (eastern Finland) was identified, 37 of whom (aged 65 […]

Haslam, Catherine, Moss, Zoë, Hodder, Kathryn

A growing trend in memory rehabilitation is to combine learning principles to enhance treatment effects. While this makes intuitive sense, little is known about the added value of incorporating each method. A further complication is that some interventions, although primarily based on one learning principle, actually incorporate several, which again adds to the difficulty in […]