This database contains 22 studies, archived under the term: "treatment"
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Response to cholinesterase inhibitors affects lifespan in Alzheimer’s disease
Background: A varying response to cholinesterase inhibitor (ChEI) treatment has been reported among patients with Alzheimer’s disease (AD). Whether the individual-specific response, specific ChEI agent or dose affects mortality is unclear. We aimed to examine the relationship between the 6-month response to ChEI and lifespan. Methods: Six hundred and eighty-one deceased patients with a clinical […]
Treatment of sleep apnoea syndrome decreases cognitive decline in patients with Alzheimer’s disease
Troussière, Anne-Cécile,
Monaca Charley, Christelle,
Salleron, Julia,
Richard, Florence,
Delbeuck, Xavier,
Derambure, Philippe,
Pasquier, Florence,
Bombois, Stéphanie
Background: It is essential to detect and then treat factors that aggravate Alzheimer’s disease (AD). Here, we sought to determine whether or not continuous positive airway pressure (CPAP) therapy for sleep apnoea syndrome (SAS) slows the rate of cognitive decline in mild-to-moderate AD patients.; Methods: Between January 2003 and June 2011, we included consecutive, mild-to-moderate […]
Staff training in assisted living: evaluating treatment fidelity
Teri, Linda,
McKenzie, Glenise L.,
Pike, Kenneth C.,
Farran, Carol J.,
Beck, Cornelia,
Paun, Olimpia,
LaFazia, David
Objectives: To investigate a protocol for identifying and evaluating treatment fidelity in Staff Training in Assisted-living Residences (STAR), a structured but flexible program to train direct care staff to improve care of residents with dementia.; Design: Multisite feasibility trial.; Setting: Assisted living facilities (ALFs).; Participants: Forty-four direct care staff and 36 leadership staff.; Intervention: STAR […]
Angiotensin-converting enzyme inhibitors and Alzheimer’s disease progression in older adults: results from the Réseau sur la Maladie d’Alzheimer Français cohort
Soto, Maria E.,
Abellan van Kan, Gabor,
Nourhashemi, Fati,
Gillette-Guyonnet, Sophie,
Cesari, Matteo,
Cantet, Christelle,
Rolland, Yves,
Vellas, Bruno
Objectives: To assess whether angiotensin-converting enzyme inhibitor (ACE-I) treatment is associated with less cognitive decline in older adults with Alzheimer’s disease (AD) than in those using other hypertensive or no drugs.; Design: Four-year prospective multicenter cohort study with a biannual assessment.; Setting: Memory clinics from 16 university hospitals in France.; Participants: Community-dwelling older adults with […]
A randomized clinical trial of Behavioral Activation (BA) therapy for improving psychological and physical health in dementia caregivers: results of the Pleasant Events Program (PEP)
Moore, Raeanne C.,
Chattillion, Elizabeth A.,
Ceglowski, Jennifer,
Ho, Jennifer,
von Känel, Roland,
Mills, Paul J.,
Ziegler, Michael G.,
Patterson, Thomas L.,
Grant, Igor,
Mausbach, Brent T.
Dementia caregiving is associated with elevations in depressive symptoms and increased risk for cardiovascular diseases (CVD). This study evaluated the efficacy of the Pleasant Events Program (PEP), a 6-week Behavioral Activation intervention designed to reduce CVD risk and depressive symptoms in caregivers. One hundred dementia family caregivers were randomized to either the 6-week PEP intervention […]
Problem adaptation therapy for older adults with major depression and cognitive impairment: A randomized clinical trial
Kiosses, Dimitris N.,
Ravdin, Lisa D.,
Gross, James J.,
Raue, Patrick,
Kotbi, Nabil,
Alexopoulos, George S.
IMPORTANCE: Problem adaptation therapy (PATH) is a treatment for older adults with major depression, cognitive impairment (from mild cognitive deficits to moderate dementia), and disability. Antidepressants have limited efficacy in this population and psychosocial interventions are inadequately investigated. OBJECTIVE: To test the efficacy of 12-week PATH vs supportive therapy for cognitively impaired patients (ST-CI) in […]
Efficacy of memantine in PDD and DLB: an extension study including washout and open-label treatment
Johansson, C.,
Ballard, C.,
Hansson, O.,
Palmqvist, S.,
Minthon, L.,
Aarsland, D.,
Londos, E.
Objective: This 30-week extension trial was a continuation of the first double-blind randomized controlled trial (RCT) to study memantine in dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD). The objective was to evaluate the presence of recurrence of symptoms upon drug withdrawal. Furthermore, the aim was to explore washout dynamics in order to […]
Medication adherence in patients with dementia: An Austrian cohort study
Haider, Bernhard,
Schmidt, Reinhold,
Schweiger, Christine,
Forstner, Thomas,
Labek, Anna,
Lampl, Christian
Sustained treatment with effective doses of cholinesterase inhibitors or memantine is crucial to transfer treatment effects in dementia. Numerous studies, with often small samples sizes, describe low adherence rates. The purpose of current study was to examine the medical adherence of antidementia therapy in Austria. We analyzed the data of 10 Austrian Health Insurance Funds, […]
Trazodone improves sleep parameters in Alzheimer disease patients: A randomized, double-blind, and placebo-controlled study
Camargos, Einstein F.,
Louzada, Luciana L.,
Quintas, Juliana L.,
Naves, Janeth O.S.,
Louzada, Fernando M.,
Nóbrega, Otávio T.
Objectives: There are no randomized clinical trials regarding efficacy of trazodone in the treatment of sleep disturbances (SD) in patients with Alzheimer disease (AD). We tested the efficacy and safety of trazodone to treat SD in patients with AD. Design: We conducted a double-blind, randomized and controlled trial during periods of 7–9 days at baseline […]