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This database contains 34 studies, archived under the term: "stimulation"

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Transcranial Magnetic Stimulation to Address Mild Cognitive Impairment in the Elderly: A Randomized Controlled Study

Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique with potential to improve memory. Mild cognitive impairment (MCI), which still lacks a specific therapy, is a clinical syndrome associated with increased risk of dementia. This study aims to assess the effects of high-frequency repetitive TMS (HF rTMS) on everyday memory of the elderly with […]

Effects of multisensory stimulation on cognition, depression and anxiety levels of mildly-affected Alzheimer’s patients

Aims: The purpose of this study was to investigate and assess the effects of musical therapy, painting inanimate–animate object pictures, and orientation to time–place–person interventions on the cognitive state, depression, and anxiety levels of mildly-affected Alzheimer’s patients. Methods: The study using a quasi-experimental design was conducted with 27 mildly-affected Alzheimer’s patients. The effects of the […]

Brain stimulation in Alzheimer disease

Recent studies have reported enhanced performance on specific cognitive tasks in patients with several types of neurological disease, after receiving non invasive brain stimulation (BS), i.e., repetitive Transcranial Magnetic Stimulation (rTMS) or transcranial Direct Current Stimulation (tDCS) to specific cortical areas. In addition, persistent beneficial effects of off-line rTMS on sentence comprehension in Alzheimer disease […]

Randomized trial of deep brain stimulation for Parkinson disease: thirty-six-month outcomes

Objectives: Our objective was to compare long-term outcomes of deep brain stimulation (DBS) of the globus pallidus interna (GPi) and subthalamic nucleus (STN) for patients with Parkinson disease (PD) in a multicenter randomized controlled trial.; Methods: Patients randomly assigned to GPi (n = 89) or STN DBS (n = 70) were followed for 36 months. […]

Increased cerebral metabolism after 1 year of deep brain stimulation in Alzheimer disease

Background: The importance of developing unique, neural circuitry-based treatments for the cognitive and neuropsychiatric symptoms of Alzheimer disease (AD) was the impetus for a phase I study of deep brain stimulation (DBS) in patients with AD that targeted the fornix.; Objective: To test the hypotheses that DBS would increase cerebral glucose metabolism in cortical and […]

Effects of multimodal nondrug therapy on dementia symptoms and need for care in nursing home residents with degenerative dementia: a randomized-controlled study with 6-month follow-up

Objectives: To determine the efficacy of multimodal, nondrug therapy on symptoms of dementia and need for care in institutionalized individuals with degenerative dementia.; Design: Randomized, controlled, longitudinal trial. Data were analyzed using multiple linear regression.; Setting: Five German nursing homes.; Participants: One hundred thirty-nine nursing home residents with primary degenerative dementia (Mini-Mental State Examination score […]

Non-invasive brain stimulation improves object-location learning in the elderly

Remembering the location of objects, an integral part of everyday life, is known to decline with advancing age and early in the course of neurodegenerative dementia. Here, we aimed to test if object-location learning and its retention could be modified by noninvasive brain stimulation. In a group of 20 elderly (mean age 62.1 years) right-handed […]

Negative impact of borderline global cognitive scores on quality of life after subthalamic nucleus stimulation in Parkinson’s disease

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) significantly improves quality of life (QoL) in Parkinson’s disease (PD). Dementia is considered as a contraindication for STN-DBS. However, no controlled study assessed the impact of STN-DBS on the QoL and motor outcome in PD patients with a borderline global cognitive impairment. We studied clinical baseline […]

Effects of low versus high frequencies of repetitive transcranial magnetic stimulation on cognitive function and cortical excitability in Alzheimer’s dementia

The aim of the study was to compare the long-term efficacy of high versus low frequency repetitive transcranial magnetic stimulation (rTMS), applied bilaterally over the dorsolateral prefrontal cortex (DLPFC), on cognitive function and cortical excitability of patients with Alzheimer’s disease (AD). Forty-five AD patients were randomly classified into three groups. The first two groups received […]

Improved language performance in Alzheimer disease following brain stimulation

Objectives: Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a possible treatment for the cognitive deficits associated with Alzheimer disease (AD). The aim of this study was to assess the long-term effects, on cognitive performance, of rTMS applied to the left dorsolateral prefrontal cortex (DLPFC) in AD patients.; Methods: Ten AD patients were randomly […]

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