Jelcic, Nela, Cagnin, Annachiara, Meneghello, Francesca, Turolla, Andrea, Ermani, Mario, Dam, Mauro

Background: Episodic memory and semantic abilities deteriorate early in Alzheimer disease (AD). Since the cognitive system includes interconnected and reciprocally influenced neuronal networks, the authors hypothesized that stimulation of lexical-semantic abilities may benefit semantically structured episodic memory.; Objective: To investigate the effects of lexical-semantic stimulation (LSS) on verbal communication and episodic memory in early AD.; […]

Hampstead, Benjamin M., Sathian, Krish, Phillips, Pamela A., Amaraneni, Akshay, Delaune, William R., Stringer, Anthony Y.

Objective: To evaluate the efficacy of mnemonic strategy training versus a matched-exposure control condition and to examine the relationship between training-related gains, neuropsychological abilities, and medial temporal lobe volumetrics in patients with amnestic mild cognitive impairment (aMCI) and age-matched healthy controls.; Method: Twenty-three of 45 screened healthy controls and 29 of 42 screened patients with […]

Venneri, Annalena, McGeown, William J., Shanks, Michael F.

Clinical trials of cholinesterase inhibitor (ChEI) drugs, although generally reporting only minimal improvements in patients with Alzheimer’s disease (AD), indicate that a subgroup of patients may respond substantially to treatment. This study aimed to assess the clinically variable ChEI treatment effects in a group of patients with mild AD using a semantic association and an […]

Calley, Clifford S., Tillman, Gail D., Womack, Kyle, Moore, Patricia, Hart, John, Jr., Kraut, Michael A.

Objective: Compare subjective reports of both memory and word-finding deficits to clinical diagnosis and objective neuropsychological testing.; Background: With the increasing number of aging individuals with cognitive impairments, effective screening measures would improve the likelihood of detection. Subjective reports of symptoms are typically obtained in clinical settings, yet the validity of these reports is relatively […]

Mormont, E., Jamart, J., Robaye, L.

Background: The five-word test (FWT) uses semantic clues to optimize the encoding and retrieval of 5 items. Our objective was to assess the validity of the FWT as a measure of episodic memory when compared with the Free and Cued Selective Reminding Test (FCSRT), and its ability to distinguish participants with any dementia and especially […]

Goudour, Amandine, Samson, Séverine, Bakchine, Serge, Ehrlé, Nathalie

The purpose of this study was to assess the effects of semantic stimulation of Alzheimer’s patients on semantic memory comparatively to psychological support. We conducted semantic training with two target categories (musical instruments and human actions), because these concepts were massively failed in previous data collected in Alzheimer’s disease. Ten patients (57-78 year old, MMSE […]