Zhang, Y., Kivipelto, M., Solomon, A., Wimo, A.

Risk scores based on modifiable factors have recently been developed for dementia. This study aims to estimate the cost-effectiveness of a potential preventive intervention program meant to lower the score related to increased dementia risk. Analyses were based on a Markov model adapted to Swedish circumstances. Risk score categories and risk probabilities were derived from […]

Baker, Laura D., Bayer-Carter, Jennifer L., Skinner, Jeannine, Montine, Thomas J., Cholerton, Brenna A., Callaghan, Maureen, Leverenz, James B., Walter, Brooke K., Tsai, Elaine, Postupna, Nadia, Lampe, Johanna, Craft, Suzanne

We previously showed that amyloid-β 1-42 (Aβ(42)) levels in cerebrospinal fluid (CSF) were markedly altered in response to a 4-week dietary intervention in normal aging and mild cognitive impairment (MCI). Here, we re-examined the data to assess whether diet-induced effects on CSF Aβ(42) were modulated by high intensity physical activity (hi-PA). Normal older adults (n […]

Anstey, Kaarin J., Bahar-Fuchs, Alex, Herath, Pushpani, Rebok, George W., Cherbuin, Nicolas

Background: Disappointing results from clinical trials of disease-modifying interventions for Alzheimer’s dementia (AD), along with reliable identification of modifiable risk factors in mid life from epidemiological studies, have contributed to calls to invest in risk-reduction interventions. It is also well known that AD-related pathological processes begin more than a decade before the development of clinical […]

Chang, M., Jonsson, P. V., Snaedal, J., Bjornsson, S., Saczynski, J. S., Aspelund, T., Eiriksdottir, G., Jonsdottir, M. K., Lopez, O. L., Harris, T. B., Gudnason, V., Launer, L. J.

Background: There are few studies on the long-term associations of physical activity (PA) to cognition. Here, we examine the association of midlife PA to late-life cognitive function and dementia.; Methods: The sample consisted of a population-based cohort of men and women (born in 1907-1935) participating in the Age Gene/Environment Susceptibility-Reykjavik Study. The interval between the […]