Miah, I. P., Olde Dubbelink, K. T., Stoffers, D., Deijen, J. B., Berendse, H. W.

Background and Purpose: The aim of this study was to establish the cognitive profile of newly diagnosed untreated (de novo) patients with Parkinson’s disease (PD) and more advanced, treated patients, and to determine the effects of dopamine (DA) replacement therapy.; Methods: A cohort of 23 de novo patients, 55 mild to moderately advanced, medicated PD […]

Tan, R. S.

Objective: To describe the effect of testosterone replacement therapy (TRT) on the brain activity of two demented, hypogonadal male patients with early and late-stage Alzheimer’s disease (AD), respectively.; Methods: We describe the clinical and positron emission tomography (PET) findings for two individuals, one with early stage and the other with late-stage Alzheimer’s disease, before and […]

Raetz, Paige B., LeBlanc, Linda A., Baker, Jonathan C., Hilton, Laura C.

Paired-stimulus preference assessments have been used effectively with individuals with dementia to identify stimuli to increase engagement and to minimize negative affect and problem behavior.We evaluated whether a multiple-stimulus without replacement preference assessment could be used with older adults with dementia and whether preferences remained stable over time. Seven participants completed preference assessments and confirmatory […]

Manson, JoAnn E., Chlebowski, Rowan T., Stefanick, Marcia L., Aragaki, Aaron K., Rossouw, Jacques E., Prentice, Ross L., Anderson, Garnet, Howard, Barbara V., Thomson, Cynthia A., LaCroix, Andrea Z., Wactawski-Wende, Jean, Jackson, Rebecca D., Limacher, Marian, Margolis, Karen L., Wassertheil-Smoller, Sylvia, Beresford, Shirley A., Cauley, Jane A., Eaton, Charles B., Gass, Margery, Hsia, Judith, Johnson, Karen C., Kooperberg, Charles, Kuller, Lewis H., Lewis, Cora E., Liu, Simin, Martin, Lisa W., Ockene, Judith K., O’Sullivan, Mary Jo, Powell, Lynda H., Simon, Michael S., Van Horn, Linda, Vitolins, Mara Z., Wallace, Robert B.

Importance: Menopausal hormone therapy continues in clinical use but questions remain regarding its risks and benefits for chronic disease prevention.; Objective: To report a comprehensive, integrated overview of findings from the 2 Women’s Health Initiative (WHI) hormone therapy trials with extended postintervention follow-up.; Design, Setting, and Participants: A total of 27,347 postmenopausal women aged 50 […]

Jacobs, Emily G., Kroenke, Candyce, Lin, Jue, Epel, Elissa S., Kenna, Heather A., Blackburn, Elizabeth H., Rasgon, Natalie L.

Apolipoprotein-ε4 (APOE-ε4) is a major genetic risk factor for cognitive decline, Alzheimer’s disease (AD) and early mortality. An accelerated rate of biological aging could contribute to this increased risk. Here, we determined whether APOE-ε4 status impacts leukocyte telomere length (TL) and the rate of cellular senescence in healthy mid-life women and, further, whether hormone replacement […]