van den Bogaard, S. J. A., Dumas, E. M., Hart, E. P., Milles, J., Reilmann, R., Stout, J. C., Craufurd, D., Gibbard, C. R., Tabrizi, S. J., van Buchem, M. A., van der Grond, J., Roos, R. A. C.

Background and Purpose: MTI is a quantitative MR imaging technique that has recently demonstrated structural integrity differences between controls and patients with HD. Potentially, MTI can be used as a biomarker for monitoring disease progression. To establish the value of MTI as a biomarker, we aimed to examine the change in these measures during the […]

Miyoshi, F., Ogawa, T., Kitao, S.- i., Kitayama, M., Shinohara, Y., Takasugi, M., Fujii, S., Kaminou, T.

Background and Purpose: Progressive changes in the substantia nigra pars compacta and locus ceruleus of patients with Parkinson disease and Alzheimer disease visualized by neuromelanin MRI and cardiac postganglionic sympathetic nerve function on (123)I-metaiodobenzylguanidine scintigraphy have not been fully evaluated. We compared the diagnostic value of these modalities among patients with early Parkinson disease, late […]

Bondi, Mark W., Edmonds, Emily C., Jak, Amy J., Clark, Lindsay R., Delano-Wood, Lisa, McDonald, Carrie R., Nation, Daniel A., Libon, David J., Au, Rhoda, Galasko, Douglas, Salmon, David P.

We compared two methods of diagnosing mild cognitive impairment (MCI): conventional Petersen/Winblad criteria as operationalized by the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and an actuarial neuropsychological method put forward by Jak and Bondi designed to balance sensitivity and reliability. 1,150 ADNI participants were diagnosed at baseline as cognitively normal (CN) or MCI via ADNI criteria […]