Lautenschlager, Nicola T., Cox, Kay L., Flicker, Leon, Foster, Jonathan K., van Bockxmeer, Frank M., Xiao, Jianguo, Greenop, Kathryn R., Almeida, Osvaldo P.

Context: Many observational studies have shown that physical activity reduces the risk of cognitive decline; however, evidence from randomized trials is lacking. Objective: To determine whether physical activity reduces the rate of cognitive decline among older adults at risk. Design and Setting: Randomized controlled trial of a 24-week physical activity intervention conducted between 2004 and […]

Raaphorst, Joost, Beeldman, Emma, Schmand, Ben, Berkhout, Joris, Linssen, Wim H. J. P., van den Berg, Leonard H., Pijnenburg, Yolande A., Grupstra, Hepke F., Weikamp, Janneke G., Schelhaas, H. Jurgen, Papma, Janne M., van Swieten, John C., de Visser, Marianne, de Haan, Rob J.

Objective: The assessment of behavioral disturbances in amyotrophic lateral sclerosis (ALS) is important because of the overlap with the behavioral variant of frontotemporal dementia (ALS-bvFTD). Motor symptoms and dysarthria are not taken into account in currently used behavioral questionnaires. We examined the clinimetric properties of a new behavioral questionnaire for patients with ALS (Amyotrophic Lateral […]

Nolan, John M., Loskutova, Ekaterina, Howard, Alan, Mulcahy, Riona, Moran, Rachel, Stack, Jim, Bolger, Maggie, Coen, Robert F., Dennison, Jessica, Akuffo, Kwadwo Owusu, Owens, Niamh, Power, Rebecca, Thurnham, David, Beatty, Stephen

Background: Patients with Alzheimer’s disease (AD) exhibit significantly less macular pigment (MP) and poorer vision when compared to control subjects. Objective: To investigate supplementation with the macular carotenoids on MP, vision, and cognitive function in patients with AD versus controls. Methods: A randomized, double-blind clinical trial with placebo and active arms. 31 AD patients and […]