Blackburn, Daniel J., Krishnan, Kailash, Fox, Lydia, Ballard, Clive, Burns, Alistair, Ford, Gary A., Mant, Jonathan, Passmore, Peter, Pocock, Stuart, Reckless, John, Sprigg, Nikola, Stewart, Rob, Wardlaw, Joanna, Bath, Philip M. W.

Background: Stroke is a common cause of cognitive impairment and dementia. However, effective strategies for reducing the risk of post-stroke dementia remain undefined. Potential strategies include intensive lowering of blood pressure and/or lipids.; Design: multi-centre prospective randomised open-label blinded-endpoint controlled partial-factorial phase IV trial in secondary and primary care.; Participants: 100 participants from 30 UK […]

Rivasseau Jonveaux, T., Batt, M., Fescharek, R., Benetos, A., Trognon, A., Bah Chuzeville, S., Pop, A., Jacob, C., Yzoard, M., Demarche, L., Soulon, L., Malerba, G., Bouvel, B.

The French Alzheimer Plan 2008-2012 anticipates the implementation of new Units specialized in cognitive rehabilitation and psycho-behavioral therapy of Alzheimer’s disease (AD) patients. Conceived for AD and other dementia patients of all ages, their objectives are to propose a cognitive rehabilitation program, to prevent or treat psycho-behavioral crises, and to provide support and educational therapy […]

Iliffe, Steve, Wilcock, Jane, Griffin, Mark, Jain, Priya, Thuné-Boyle, Ingela, Koch, Tamar, Lefford, Frances

Background: The National Dementia Strategy seeks to enhance general practitioners’ diagnostic and management skills in dementia. Early diagnosis in dementia within primary care is important as this allows those with dementia and their family care networks to engage with support services and plan for the future. There is, however, evidence that dementia remains under-detected and […]

Streater, Amy, Spector, Aimee, Aguirre, Elisa, Hoe, Juanita, Hoare, Zoe, Woods, Robert, Russell, Ian, Orrell, Martin

Background: Cognitive Stimulation Therapy (CST) is a psychosocial evidence-based group intervention for people with dementia recommended by the UK NICE guidelines. In clinical trials, CST has been shown to improve cognition and quality of life, but little is known about the best way of ensuring implementation of CST in practice settings. A recent pilot study […]

Taipale, Heidi, Tanskanen, Antti, Koponen, Marjaana, Tolppanen, Anna-Maija, Tiihonen, Jari, Hartikainen, Sirpa

The objective of this study was to investigate the prevalence of acetylcholinesterase inhibitor (AChEI) and memantine use, duration of treatment, concomitant use of these drugs, and factors associated with the discontinuation of AChEI therapy during 2006-2009. We utilized data from a nationwide sample of community-dwelling individuals with a clinically verified Alzheimer’s disease diagnosed during the […]

Snyder, Peter J., Jackson, Colleen E., Petersen, Ronald C., Khachaturian, Ara S., Kaye, Jeffrey, Albert, Marilyn S., Weintraub, Sandra

The demand for rapidly administered, sensitive, and reliable cognitive assessments that are specifically designed for identifying individuals in the earliest stages of cognitive decline (and to measure subtle change over time) has escalated as the emphasis in Alzheimer’s disease clinical research has shifted from clinical diagnosis and treatment toward the goal of developing presymptomatic neuroprotective […]

Rapp, Michael A., Mell, Thomas, Majić, Tomislav, Treusch, Yvonne, Nordheim, Johanna, Niemann-Mirmehdi, Mechthild, Gutzmann, Hans, Heinz, Andreas

Objective: To test the effect of a complex guideline-based intervention on agitation and psychotropic prescriptions.; Design, Setting, Participants: Cluster randomized controlled trial (VIDEANT) with blinded assessment of outcome in 18 nursing homes in Berlin, Germany, comprising 304 dementia patients.; Intervention: Training, support, and activity therapy intervention, delivered at the level of each nursing home, focusing […]

Liu, Yawu, Mattila, Jussi, Ruiz, Miguel Ángel Muñoz, Paajanen, Teemu, Koikkalainen, Juha, van Gils, Mark, Herukka, Sanna-Kaisa, Waldemar, Gunhild, Lötjönen, Jyrki, Soininen, Hilkka

Purpose: To compare the accuracies of predicting AD conversion by using a decision support system (PredictAD tool) and current research criteria of prodromal AD as identified by combinations of episodic memory impairment of hippocampal type and visual assessment of medial temporal lobe atrophy (MTA) on MRI and CSF biomarkers.; Methods: Altogether 391 MCI cases (158 […]