Nakagawa, Kiyotaka, Kiko, Takehiro, Miyazawa, Taiki, Carpentero Burdeos, Gregor, Kimura, Fumiko, Satoh, Akira, Miyazawa, Teruo

Phospholipid hydroperoxides (PLOOH) accumulate abnormally in the erythrocytes of dementia patients, and dietary xanthophylls (polar carotenoids such as astaxanthin) are hypothesised to prevent the accumulation. In the present study, we conducted a randomised, double-blind, placebo-controlled human trial to assess the efficacy of 12-week astaxanthin supplementation (6 or 12 mg/d) on both astaxanthin and PLOOH levels in […]

Burns, Alistair, Perry, Elaine, Holmes, Clive, Francis, Paul, Morris, Julie, Howes, Melanie-Jayne R., Chazot, Paul, Lees, George, Ballard, Clive

Background/aims: Behavioural and psychological symptoms (BPSD) are frequent in people with Alzheimer’s disease and cause considerable stress to patients and their carers. Antipsychotics have been widely used as a first-line treatment, resulting in an estimated 1,800 excess strokes and 1,600 excess deaths in the UK alone. Safe and effective alternatives are urgently needed. Based upon […]

Jimbo, Daiki, Kimura, Yuki, Taniguchi, Miyako, Inoue, Masashi, Urakami, Katsuya

Objective: Recently, the importance of non-pharmacological therapies for dementia has come to the fore. In the present study, we examined the curative effects of aromatherapy in dementia in 28 elderly people, 17 of whom had Alzheimer’s disease (AD).; Methods: After a control period of 28 days, aromatherapy was performed over the following 28 days, with […]

van der Ploeg, Eva S, Eppingstall, Barbara, O'Connor, Daniel W.

Background: The agitated behaviours that accompany dementia (e.g. pacing, aggression, calling out) are stressful to both nursing home residents and their carers and are difficult to treat. Increasingly more attention is being paid to alternative interventions that are associated with fewer risks than pharmacology. Lavandula angustifolia (lavender) has been thought, for centuries, to have soothing […]

O'Connor, Daniel W., Eppingstall, Barbara, Taffe, John, van der Ploeg, Eva S

Background: Lavender essential oil shows evidence of sedative properties in neurophysiological and animal studies but clinical trials of its effectiveness as a treatment of agitation in people with dementia have shown mixed results. Study methods have varied widely, however, making comparisons hazardous. To help remedy previous methodological shortcomings, we delivered high grade lavender oil in […]

Martínez-Lapiscina, Elena H, Clavero, P., Toledo, E., San Julian, B., Sanchez-Tainta, A., Corella, D., Lamuela-Raventos, R. M., Martinez, J. A., Martinez-Gonzalez, M. Á.

Objective: To assess the effect on cognition of a controlled intervention testing Mediterranean diets (MedDiet).; Design: Randomized trial after 6.5 years of nutritional intervention.; Setting: Eight primary care centers affiliated to the University of Navarra.; Participants: A random subsample of 285 participants (95 randomly allocated to each of 3 groups) of the PREDIMED-NAVARRA trial. All […]

Fu, Chieh-Yu, Moyle, Wendy, Cooke, Marie

Background: Aromatherapy and hand massage therapies have been reported to have some benefit for people with dementia who display behavioural symptoms; however there are a number of limitations of reported studies. The aim is to investigate the effect of aromatherapy (3% lavender oil spray) with and without hand massage on disruptive behaviour in people with […]

Berr, Claudine, Portet, Florence, Carrière, Isabelle, Akbaraly, Tasnime N., Feart, Catherine, Gourlet, Véronique, Combe, Nicole, Barberger-Gateau, Pascale, Ritchie, Karen

Background: Olive oil is a major component of the Mediterranean diet suggested to be beneficial to counteract Alzheimer’s disease.; Aim Of the Study: Our objective was to examine the association between olive oil use, cognitive deficit and cognitive decline in a large elderly population.; Methods: We followed 6,947 subjects with a brief baseline food frequency […]