This database contains 174 studies, archived under the term: "physiopathology"
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Transcranial Magnetic Stimulation to Address Mild Cognitive Impairment in the Elderly: A Randomized Controlled Study
Drumond Marra, Hellen Livia,
Myczkowski, Martin Luiz,
Maia Memória, Cláudia,
Arnaut, Débora,
Leite Ribeiro, Philip,
Sardinha Mansur, Carlos Gustavo,
Lancelote Alberto, Rodrigo,
Boura Bellini, Bianca,
Alves Fernandes da Silva, Adriano,
Tortella, Gabriel,
Ciampi de Andrade, Daniel,
Teixeira, Manoel Jacobsen,
Forlenza, Orestes Vicente,
Marcolin, Marco Antonio
Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique with potential to improve memory. Mild cognitive impairment (MCI), which still lacks a specific therapy, is a clinical syndrome associated with increased risk of dementia. This study aims to assess the effects of high-frequency repetitive TMS (HF rTMS) on everyday memory of the elderly with […]
FMRI connectivity analysis of acupuncture effects on the whole brain network in mild cognitive impairment patients
Feng, Yuanyuan,
Bai, Lijun,
Ren, Yanshuang,
Chen, Shangjie,
Wang, Hu,
Zhang, Wensheng,
Tian, Jie
The increased risk for the elderly with mild cognitive impairment (MCI) to progress to Alzheimer’s disease makes it an appropriate condition for investigation. While the use of acupuncture as a complementary therapeutic method for treating MCI is popular in certain parts of the world, the underlying mechanism is still elusive. We sought to investigate the […]
The effects of ramipril in individuals at risk for Alzheimer’s disease: results of a pilot clinical trial
Wharton, Whitney,
Stein, James H.,
Korcarz, Claudia,
Sachs, Jane,
Olson, Sandra R.,
Zetterberg, Henrik,
Dowling, Maritza,
Ye, Shuyun,
Gleason, Carey E.,
Underbakke, Gail,
Jacobson, Laura E.,
Johnson, Sterling C.,
Sager, Mark A.,
Asthana, Sanjay,
Carlsson, Cynthia M.
Research shows that certain antihypertensives taken during midlife confer Alzheimer’s disease (AD) related benefits in later life. We conducted a clinical trial to evaluate the extent to which the angiotensin converting enzyme inhibitor (ACE-I), ramipril, affects AD biomarkers including cerebrospinal fluid (CSF) amyloid-β (Aβ) levels and ACE activity, arterial function, and cognition in participants with […]
Randomized trial of deep brain stimulation for Parkinson disease: thirty-six-month outcomes
Weaver, Frances M.,
Follett, Kenneth A.,
Stern, Matthew,
Luo, Ping,
Harris, Crystal L.,
Hur, Kwan,
Marks, William J., Jr.,
Rothlind, Johannes,
Sagher, Oren,
Moy, Claudia,
Pahwa, Rajesh,
Burchiel, Kim,
Hogarth, Penelope,
Lai, Eugene C.,
Duda, John E.,
Holloway, Kathryn,
Samii, Ali,
Horn, Stacy,
Bronstein, Jeff M.,
Stoner, Gatana,
Starr, Philip A.,
Simpson, Richard,
Baltuch, Gordon,
De Salles, Antonio,
Huang, Grant D.,
Reda, Domenic J.
Objectives: Our objective was to compare long-term outcomes of deep brain stimulation (DBS) of the globus pallidus interna (GPi) and subthalamic nucleus (STN) for patients with Parkinson disease (PD) in a multicenter randomized controlled trial.; Methods: Patients randomly assigned to GPi (n = 89) or STN DBS (n = 70) were followed for 36 months. […]
A community-based approach to trials of aerobic exercise in aging and Alzheimer’s disease
Vidoni, Eric D.,
Van Sciver, Angela,
Johnson, David K.,
He, Jinghua,
Honea, Robyn,
Haines, Brian,
Goodwin, Jami,
Laubinger, M. Pat,
Anderson, Heather S.,
Kluding, Patricia M.,
Donnelly, Joseph E.,
Billinger, Sandra A.,
Burns, Jeffrey M.
The benefits of exercise for aging have received considerable attention in both the popular and academic press. The putative benefits of exercise for maximizing cognitive function and supporting brain health have great potential for combating Alzheimer’s disease (AD). Aerobic exercise offers a low-cost, low-risk intervention that is widely available and may have disease modifying effects. […]
Cognitive intervention response is related to habitual physical activity in older adults
Thiel, Christian,
Vogt, Lutz,
Tesky, Valentina A.,
Meroth, Linda,
Jakob, Marion,
Sahlender, Sandra,
Pantel, Johannes,
Banzer, Winfried
Background and Aims: This study analysed the associations between physical activity and the effects of cognitive training on perceived cognitive functioning and life satisfaction in older adults.; Methods: A sample of 114 intervention group participants (65-89 yrs) received weekly group sessions of cognitive stimulation for two months. This sample was stratified into groups according to […]