Kersten, Hege, Wyller, Torgeir B., Molden, Espen

Background: To compare measures of anticholinergic activity between metabolic phenotypes of the polymorphic enzymes cytochrome P450 2D6 (CYP2D6) and CYP2C19 in the elderly patients exposed to anticholinergic agents.; Methods: Long-term nursing home patients (n = 80) with an anticholinergic drug scale (ADS) score ≥3 were recruited from 22 nursing homes in Norway. Based on pharmacogenetic […]

Jesso, S., Morlog, D., Ross, S., Pell, M. D., Pasternak, S. H., Mitchell, D. G. V., Kertesz, A., Finger, E. C.

Patients with behavioural variant frontotemporal dementia demonstrate abnormalities in behaviour and social cognition, including deficits in emotion recognition. Recent studies suggest that the neuropeptide oxytocin is an important mediator of social behaviour, enhancing prosocial behaviours and some aspects of emotion recognition across species. The objective of this study was to assess the effects of a […]

Haïk, Stéphane, Marcon, Gabriella, Mallet, Alain, Tettamanti, Mauro, Welaratne, Arlette, Giaccone, Giorgio, Azimi, Shohreh, Pietrini, Vladimiro, Fabreguettes, Jean-Roch, Imperiale, Daniele, Cesaro, Pierre, Buffa, Carlo, Aucan, Christophe, Lucca, Ugo, Peckeu, Laurène, Suardi, Silvia, Tranchant, Christine, Zerr, Inga, Houillier, Caroline, Redaelli, Veronica, Vespignani, Hervé, Campanella, Angela, Sellal, François, Krasnianski, Anna, Seilhean, Danielle, Heinemann, Uta, Sedel, Frédéric, Canovi, Mara, Gobbi, Marco, Di Fede, Giuseppe, Laplanche, Jean-Louis, Pocchiari, Maurizio, Salmona, Mario, Forloni, Gianluigi, Brandel, Jean-Philippe, Tagliavini, Fabrizio

Background: Creutzfeldt-Jakob disease (CJD) is a fatal, untreatable prion encephalopathy. Previous studies showed that doxycycline is effective in in-vitro and in-vivo models of disease, and patients with CJD who received compassionate treatment with doxycycline showed increased survival time compared with historical series. We therefore did a randomised, double-blind study of doxycycline versus placebo in CJD.; […]

Ancelin, Marie-Laure, Carrière, Isabelle, Barberger-Gateau, Pascale, Auriacombe, Sophie, Rouaud, Olivier, Fourlanos, Spiros, Berr, Claudine, Dupuy, Anne-Marie, Ritchie, Karen

The aim of this prospective cohort study was to evaluate the effects of lipid lowering agent (LLA) intake on cognitive function in 6,830 community-dwelling elderly persons. Cognitive performance (global cognitive functioning, visual memory, verbal fluency, psychomotor speed, and executive function), clinical diagnosis of dementia, and fibrate and statin use, were evaluated at baseline, and 2, […]