Cazzola, Roberta, Rondanelli, Mariangela, Faliva, Milena, Cestaro, Benvenuto

A randomized, double-blind placebo-controlled clinical trial was carried out to assess the efficacy of a docosahexenoic acid (DHA)-phospholipids, melatonin and tryptophan supplemented diet in improving the erythrocyte oxidative stress, membrane fluidity and membrane-bound enzyme activities of elderly subjects suffering from mild cognitive impairment (MCI). These subjects were randomly assigned to the supplement group (11 subjects, […]

Morillas-Ruiz, J. M., Rubio-Perez, J. M., Albaladejo, M. D., Zafrilla, P., Parra, S., Vidal-Guevara, M. L.

Background: A large body of evidence supports a role of oxidative stress in Alzheimer disease (AD) and in cerebrovascular disease. Blood levels of homocysteine may be increased in AD and hyperhomocysteinemia may contribute to disease pathophysiology by vascular and direct neurotoxic mechanisms. Even in the absence of vitamin deficiency, plasma total homocysteine (tHcy) concentration may […]

Cornelli, Umberto

A formula (formula F) was prepared to counteract oxidative stress (OS) in the brain. The formula contained the most common antioxidants and was intended to: (a) protect proteins, lipids, DNA and proteoglycans from oxidation (carnosine, coenzyme Q(10), vitamin E, vitamin C, beta-carotene, selenium, L-cysteine and ginkgo biloba); (b) reduce homocysteine (HCy) blood levels (vitamins B(6), […]

Lloret, Ana, Badía, Mari-Carmen, Mora, Nancy J., Pallardó, Federico V., Alonso, Maria-Dolores, Viña, Jose

There is controversy as to whether vitamin E is beneficial in Alzheimer’s disease (AD). In this study, we tested if vitamin E prevents oxidative stress and loss of cognition in AD. Fifty-seven AD patients were recruited and divided in two groups: placebo or treated with 800 IU of vitamin E per day for six months. […]

Polidori, M. Cristina, Praticó, Domenico, Mangialasche, Francesca, Mariani, Elena, Aust, Olivier, Anlasik, Timur, Mang, Ni, Pientka, Ludger, Stahl, Wilhelm, Sies, Helmut, Mecocci, Patrizia, Nelles, Gereon

A higher daily intake of fruits and vegetables in healthy elderly is associated with an improved antioxidant status in comparison to subjects consuming diets poor in fruits and vegetables, but the impact on cognitive performance is unclear. Healthy community dwellers (45 to 102 years old, n=193) underwent cognitive testing and blood withdrawal for the measurement […]