Boada, Mercè, Arranz, Francisco Javier

Background and Aims: Poor adherence to anti-dementia drugs is common among patients with Alzheimer’s disease. This study evaluated whether caregivers were more satisfied with, and patients more adherent to, transdermal rivastigmine than oral rivastigmine.; Methods: Neurologists, psychiatrists and geriatricians collected sociodemographic and clinical data from 1,078 patients and administered the Treatment Satisfaction with Medicines (SATMED-Q) […]

Salloway, S., Sperling, R., Keren, R., Porsteinsson, A. P., van Dyck, C. H., Tariot, P. N., Gilman, S., Arnold, D., Abushakra, S., Hernandez, C., Crans, G., Liang, E., Quinn, G., Bairu, M., Pastrak, A., Cedarbaum, J. M.

Objective: This randomized, double-blind, placebo-controlled, dose-ranging phase 2 study explored safety, efficacy, and biomarker effects of ELND005 (an oral amyloid anti-aggregation agent) in mild to moderate Alzheimer disease (AD).; Methods: A total of 353 patients were randomized to ELND005 (250, 1,000, or 2,000 mg) or placebo twice daily for 78 weeks. Coprimary endpoints were the […]

Weijenberg, Roxane Anthea Francesca, Lobbezoo, Frank, Knol, Dirk Lucas, Tomassen, Jori, Scherder, Erik Johan Anton

Background: Worldwide, millions of people are suffering from dementia and this number is rising. An index of quality of life (QoL) can describe the impact a disease or treatment has on a person’s wellbeing. QoL comprises many variables, including physical health and function, and mental health and function. QoL is related to masticatory ability and […]

Weijenberg, Roxane Anthea Francesca, Lobbezoo, Frank, Knol, Dirk Lucas, Tomassen, Jori, Scherder, Erik Johan Anton

Background: Worldwide, millions of people are suffering from dementia and this number is rising. An index of quality of life (QoL) can describe the impact a disease or treatment has on a person’s wellbeing. QoL comprises many variables, including physical health and function, and mental health and function. QoL is related to masticatory ability and […]

Wouters, C. J., Dautzenberg, L., Thissen, A., Dautzenberg, P. L. J.

Objectives: Since January 2008 in The Netherlands, two cholinesterase inhibitors, oral galantamine and rivastigmine transdermal patch, are registered as a one-day symptomatic treatment for Alzheimer’s disease. As no head to head study was performed yet, the objective of this study was to describe the daily practice of oral galantamine and rivastigmine transdermal patch in a […]

Stange, Inken, Bartram, Matthias, Liao, Yuye, Poeschl, Karin, Kolpatzik, Sarah, Uter, Wolfgang, Sieber, Cornel C., Stehle, Peter, Volkert, Dorothee

Objectives: Although oral nutritional supplements (ONS) are known to be effective to treat malnutrition in the elderly, evidence from nursing home populations, including individuals with dementia, is rare, especially with regard to functionality and well-being. A known barrier for ONS use among elderly is the volume that needs to be consumed, resulting in low compliance […]

Sabbagh, Marwan N., Agro, Albert, Bell, Joanne, Aisen, Paul S, Schweizer, Edward, Galasko, Douglas

Objective: To evaluate the safety and tolerability of PF-04494700, an oral inhibitor of receptor for advanced glycation end products, in patients with mild-to-moderate dementia of the Alzheimer type.; Methods: Patients aged 50 years and older who met the National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer’s Disease and Related Disorders Association criteria for Alzheimer […]

Haïk, Stéphane, Marcon, Gabriella, Mallet, Alain, Tettamanti, Mauro, Welaratne, Arlette, Giaccone, Giorgio, Azimi, Shohreh, Pietrini, Vladimiro, Fabreguettes, Jean-Roch, Imperiale, Daniele, Cesaro, Pierre, Buffa, Carlo, Aucan, Christophe, Lucca, Ugo, Peckeu, Laurène, Suardi, Silvia, Tranchant, Christine, Zerr, Inga, Houillier, Caroline, Redaelli, Veronica, Vespignani, Hervé, Campanella, Angela, Sellal, François, Krasnianski, Anna, Seilhean, Danielle, Heinemann, Uta, Sedel, Frédéric, Canovi, Mara, Gobbi, Marco, Di Fede, Giuseppe, Laplanche, Jean-Louis, Pocchiari, Maurizio, Salmona, Mario, Forloni, Gianluigi, Brandel, Jean-Philippe, Tagliavini, Fabrizio

Background: Creutzfeldt-Jakob disease (CJD) is a fatal, untreatable prion encephalopathy. Previous studies showed that doxycycline is effective in in-vitro and in-vivo models of disease, and patients with CJD who received compassionate treatment with doxycycline showed increased survival time compared with historical series. We therefore did a randomised, double-blind study of doxycycline versus placebo in CJD.; […]