Zhang, Y., Kivipelto, M., Solomon, A., Wimo, A.

Risk scores based on modifiable factors have recently been developed for dementia. This study aims to estimate the cost-effectiveness of a potential preventive intervention program meant to lower the score related to increased dementia risk. Analyses were based on a Markov model adapted to Swedish circumstances. Risk score categories and risk probabilities were derived from […]

Handels, R. L., Joore, M. A., Tran-Duy, A., Wimo, A., Wolfs, C. A., Verhey, F. R., Severens, J. L.

INTRODUCTION: The study aimed to determine the room for improvement of a perfect cerebrospinal fluid (CSF) biomarker and the societal incremental net monetary benefit of CSF in subjects with mild cognitive impairment (MCI) assuming a hypothetical disease-modifying Alzheimer’s disease (AD) treatment. METHODS: A decision model compared current practice to a perfect biomarker and to two […]

Uemura, T., Ishii, K., Miyamoto, N., Yoshikawa, T.

Background and Purpose: Recently, voxel-based statistical parametric images have been developed as additional diagnostic tools for AD. However these methods require the generation of a data base of healthy brain images. The purpose of this study was to produce and evaluate an automatic method using a data base-independent estimation system for the diagnosis of mild […]

Sullivan, Mark D., Katon, Wayne J., Lovato, Laura C., Miller, Michael E., Murray, Anne M., Horowitz, Karen R., Bryan, R. Nick, Gerstein, Hertzel C., Marcovina, Santica, Akpunonu, Basil E., Johnson, Janice, Yale, Jean Francois, Williamson, Jeff, Launer, Lenore J.

Importance: Depression has been identified as a risk factor for dementia among patients with type 2 diabetes mellitus but the cognitive domains and patient groups most affected have not been identified.; Objective: To determine whether comorbid depression in patients with type 2 diabetes accelerates cognitive decline.; Design: A 40-month cohort study of participants in the […]

Slinin, Y., Paudel, M. L., Taylor, B. C., Fink, H. A., Ishani, A., Canales, M. T., Yaffe, K., Barrett-Connor, E., Orwoll, E. S., Shikany, J. M., LeBlanc, E. S., Cauley, J. A., Ensrud, K. E.

Objective: To test the hypothesis that lower 25-hydroxyvitamin D [25(OH)D] levels are associated with a greater likelihood of cognitive impairment and risk of cognitive decline.; Methods: We measured 25(OH)D and assessed cognitive function using the Modified Mini-Mental State Examination (3MS) and Trail Making Test Part B (Trails B) in a cohort of 1,604 men enrolled […]

Schölzel-Dorenbos, Carla J M, Arons, Alexander M M, Wammes, Joost J G, Rikkert, MarcelGMOlde, Krabbe, Paul F M

Background: Index measures for health-related quality of life (HRQoL) quantify the desirability (utility) of a certain health state. The commonly used generic index measure, e.g. EuroQol: EQ-5D, may underestimate relevant areas of specific diseases, resulting in lower validity. Disease-specific index measures on the other hand combine disease-specificity and quantification of perceived quality on several health […]

Rostomian, A. H., Madison, C., Rabinovici, G. D., Jagust, W. J.

Unlabelled: The availability of new PET ligands offers the potential to measure fibrillar β-amyloid in the brain. Nevertheless, physiologic information in the form of perfusion or metabolism may still be useful in differentiating causes of dementia during life. In this study, we investigated whether early (11)C-Pittsburgh compound B ((11)C-PIB) PET frames (perfusion (11)C-PIB [pPIB]) could […]