DiSilvestro, Robert A., Joseph, Elizabeth, Zhao, Shi, Bomser, Joshua

Background: Curcumin extracts of turmeric are proposed to produce health benefits. To date, human intervention studies have focused mainly on people with existing health problems given high doses of poorly absorbed curcumin. The purpose of the current study was to check whether in healthy people, a low dose of a lipidated curcumin extract could alter […]

Blackburn, Daniel J., Krishnan, Kailash, Fox, Lydia, Ballard, Clive, Burns, Alistair, Ford, Gary A., Mant, Jonathan, Passmore, Peter, Pocock, Stuart, Reckless, John, Sprigg, Nikola, Stewart, Rob, Wardlaw, Joanna, Bath, Philip M. W.

Background: Stroke is a common cause of cognitive impairment and dementia. However, effective strategies for reducing the risk of post-stroke dementia remain undefined. Potential strategies include intensive lowering of blood pressure and/or lipids.; Design: multi-centre prospective randomised open-label blinded-endpoint controlled partial-factorial phase IV trial in secondary and primary care.; Participants: 100 participants from 30 UK […]

Sano, M., Bell, K. L., Galasko, D., Galvin, J. E., Thomas, R. G., van Dyck, C. H., Aisen, P. S.

Background: Lowering cholesterol is associated with reduced CNS amyloid deposition and increased dietary cholesterol increases amyloid accumulation in animal studies. Epidemiologic data suggest that use of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) may decrease the risk of Alzheimer disease (AD) and a single-site trial suggested possible benefit in cognition with statin treatment in AD, […]

Williamson, Jeff D., Launer, Lenore J., Bryan, R. Nick, Coker, Laura H., Lazar, Ronald M., Gerstein, Hertzel C., Murray, Anne M., Sullivan, Mark D., Horowitz, Karen R., Ding, Jingzhong, Marcovina, Santica, Lovato, Laura, Lovato, James, Margolis, Karen L., Davatzikos, Christos, Barzilay, Joshua, Ginsberg, Henry N., Linz, Peter E., Miller, Michael E.

Importance: Persons with type 2 diabetes mellitus (T2DM) are at increased risk for decline in cognitive function, reduced brain volume, and increased white matter lesions in the brain. Poor control of blood pressure (BP) and lipid levels are risk factors for T2DM-related cognitive decline, but the effect of intensive treatment on brain function and structure […]