Ellis, Ronald J., Badiee, Jayraan, Vaida, Florin, Letendre, Scott, Heaton, Robert K., Clifford, David, Collier, Ann C., Gelman, Benjamin, McArthur, Justin, Morgello, Susan, McCutchan, J. Allen, Grant, Igor

Objective: Despite immune recovery in individuals on combination antiretroviral therapy (CART), the frequency of HIV-associated neurocognitive disorders (HANDs) remains high. Immune recovery is typically achieved after initiation of ART from the nadir, or the lowest historical CD4. The present study evaluated the probability of neuropsychological impairment (NPI) and HAND as a function of CD4 nadir […]

Tate, Judith A., Snitz, Beth E., Alvarez, Karina A., Nahin, Richard L., Weissfeld, Lisa A., Lopez, Oscar, Angus, Derek C., Shah, Faraaz, Ives, Diane G., Fitzpatrick, Annette L., Williamson, Jeffrey D., Arnold, Alice M., DeKosky, Steven T., Yende, Sachin

Objectives: Severe infections, often requiring ICU admission, have been associated with persistent cognitive dysfunction. Less severe infections are more common and whether they are associated with an increased risk of dementia is unclear. We determined the association of pneumonia hospitalization with risk of dementia in well-functioning older adults.; Design: Secondary analysis of a randomized multicenter […]

Hippisley-Cox, J., Coupland, C.

Objective: To quantify the unintended effects of statins according to type, dose, and duration of use.; Design: Prospective open cohort study using routinely collected data.; Setting: 368 general practices in England and Wales supplying data to the QResearch database.; Participants: 2 004 692 patients aged 30-84 years of whom 225 922 (10.7%) were new users […]