Bradley, Mark, McElhiney, Martin, Rabkin, Judith

Background: Dihydroepiandrosterone (DHEA) has been investigated for its potential role in improving cognition in a number of patient populations. Treatment options are limited for HIV-associated neurocognitive disorders.; Objective: The authors tested the effect of DHEA administration on the cognitive functioning of HIV-positive subjects with non-major depression.; Method: The neuropsychological testing data for 60 HIV-positive patients […]

Heaton, Robert K., Franklin, Donald R., Ellis, Ronald J., McCutchan, J. Allen, Letendre, Scott L., Leblanc, Shannon, Corkran, Stephanie H., Duarte, Nichole A., Clifford, David B., Woods, Steven P., Collier, Ann C., Marra, Christina M., Morgello, Susan, Mindt, Monica Rivera, Taylor, Michael J., Marcotte, Thomas D., Atkinson, J. Hampton, Wolfson, Tanya, Gelman, Benjamin B., McArthur, Justin C., Simpson, David M., Abramson, Ian, Gamst, Anthony, Fennema-Notestine, Christine, Jernigan, Terry L., Wong, Joseph, Grant, Igor

Combination antiretroviral therapy (CART) has greatly reduced medical morbidity and mortality with HIV infection, but high rates of HIV-associated neurocognitive disorders (HAND) continue to be reported. Because large HIV-infected (HIV+) and uninfected (HIV-) groups have not been studied with similar methods in the pre-CART and CART eras, it is unclear whether CART has changed the […]

Gandhi, Nishiena S., Skolasky, Richard L., Peters, Katherine B., Moxley, Richard T. th, Creighton, Jason, Roosa, Heidi Vornbrock, Selnes, Ola A., McArthur, Justin, Sacktor, Ned

The objectives of this study are to compare the results of newer performance-based functional assessments in the study of HIV-associated neurocognitive disorders (HAND) and to correlate these functional assessments with specific levels of severity of HAND. One hundred fourteen HIV+ subjects in an existing cohort were evaluated with a medical history, neurological exam, neuropsychological test […]

Ellis, Ronald J., Badiee, Jayraan, Vaida, Florin, Letendre, Scott, Heaton, Robert K., Clifford, David, Collier, Ann C., Gelman, Benjamin, McArthur, Justin, Morgello, Susan, McCutchan, J. Allen, Grant, Igor

Objective: Despite immune recovery in individuals on combination antiretroviral therapy (CART), the frequency of HIV-associated neurocognitive disorders (HANDs) remains high. Immune recovery is typically achieved after initiation of ART from the nadir, or the lowest historical CD4. The present study evaluated the probability of neuropsychological impairment (NPI) and HAND as a function of CD4 nadir […]

Simioni, Samanta, Cavassini, Matthias, Annoni, Jean-Marie, Rimbault Abraham, Aline, Bourquin, Isabelle, Schiffer, Véronique, Calmy, Alexandra, Chave, Jean-Philippe, Giacobini, Ezio, Hirschel, Bernard, Du Pasquier, Renaud A.

Objective: To determine the prevalence of cognitive complaints and HIV-associated neurocognitive disorders (HANDs) in a cohort of aviremic HIV-positive patients. To evaluate the relevance of the HIV dementia scale to detect HANDs.; Design: Assessment of HANDs with neuropsychological tests.; Methods: Two hundred HIV-infected patients with undetectable HIV-1 RNA concentrations in the plasma, no history of […]

Simioni, S., Cavassini, M., Annoni, J.-M., Metral, M., Iglesias, K., Rimbault Abraham, A., Jilek, S., Calmy, A., Muller, H., Fayet-Mello, A., Giacobini, E., Hirschel, B., Du Pasquier, R. A.

Objective: To assess the efficacy and safety of rivastigmine for the treatment of HIV-associated neurocognitive disorders (HAND) in a cohort of long-lasting aviremic HIV+ patients.; Methods: Seventeen aviremic HIV+ patients with HAND were enrolled in a randomized, double-blind, placebo-controlled, crossover study to receive either oral rivastigmine (up to 12 mg/day for 20 weeks) followed by […]

Ragin, Ann B., D’Souza, Gypsyamber, Reynolds, Sandra, Miller, Eric, Sacktor, Ned, Selnes, Ola A., Martin, Eileen, Visscher, Barbara R., Becker, James T.

An association between platelet decline and increased risk of progression to dementia has been observed in an advanced HIV infection cohort study. This investigation evaluated the prognostic significance of platelet decline for dementia, for psychomotor slowing, and for brain injury, as quantified in vivo, in a much larger population of HIV+ men. Platelet counts and […]