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This database contains 5 studies, archived under the term: "hiv infections"

DHEA and cognition in HIV-positive patients with non-major depression

Background: Dihydroepiandrosterone (DHEA) has been investigated for its potential role in improving cognition in a number of patient populations. Treatment options are limited for HIV-associated neurocognitive disorders.; Objective: The authors tested the effect of DHEA administration on the cognitive functioning of HIV-positive subjects with non-major depression.; Method: The neuropsychological testing data for 60 HIV-positive patients […]

HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors

Combination antiretroviral therapy (CART) has greatly reduced medical morbidity and mortality with HIV infection, but high rates of HIV-associated neurocognitive disorders (HAND) continue to be reported. Because large HIV-infected (HIV+) and uninfected (HIV-) groups have not been studied with similar methods in the pre-CART and CART eras, it is unclear whether CART has changed the […]

A comparison of performance-based measures of function in HIV-associated neurocognitive disorders

The objectives of this study are to compare the results of newer performance-based functional assessments in the study of HIV-associated neurocognitive disorders (HAND) and to correlate these functional assessments with specific levels of severity of HAND. One hundred fourteen HIV+ subjects in an existing cohort were evaluated with a medical history, neurological exam, neuropsychological test […]

Cognitive dysfunction in HIV patients despite long-standing suppression of viremia

Objective: To determine the prevalence of cognitive complaints and HIV-associated neurocognitive disorders (HANDs) in a cohort of aviremic HIV-positive patients. To evaluate the relevance of the HIV dementia scale to detect HANDs.; Design: Assessment of HANDs with neuropsychological tests.; Methods: Two hundred HIV-infected patients with undetectable HIV-1 RNA concentrations in the plasma, no history of […]

A pilot study of the effects of internet-based cognitive stimulation on neuropsychological function in HIV disease

Purpose: Mild cognitive deficits associated with HIV disease can affect activities of daily living, so interventions that reduce them may have a long-term effect on quality of life. We evaluated the feasibility of a cognitive stimulation program (CSP) to improve neuropsychological test performance in HIV disease.; Methods: Sixty volunteers (30 HIV-infected) participated. The primary outcome […]

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