Bayer-Carter, Jennifer L., Green, Pattie S., Montine, Thomas J., VanFossen, Brian, Baker, Laura D., Watson, G. Stennis, Bonner, Laura M., Callaghan, Maureen, Leverenz, James B., Walter, Brooke K., Tsai, Elaine, Plymate, Stephen R., Postupna, Nadia, Wilkinson, Charles W., Zhang, Jing, Lampe, Johanna, Kahn, Steven E., Craft, Suzanne

Objective: To compare the effects of a 4-week high-saturated fat/high-glycemic index (HIGH) diet with a low-saturated fat/low-glycemic index (LOW) diet on insulin and lipid metabolism, cerebrospinal fluid (CSF) markers of Alzheimer disease, and cognition for healthy adults and adults with amnestic mild cognitive impairment (aMCI).; Design: Randomized controlled trial.; Setting: Veterans Affairs Medical Center clinical […]

Tate, Judith A., Snitz, Beth E., Alvarez, Karina A., Nahin, Richard L., Weissfeld, Lisa A., Lopez, Oscar, Angus, Derek C., Shah, Faraaz, Ives, Diane G., Fitzpatrick, Annette L., Williamson, Jeffrey D., Arnold, Alice M., DeKosky, Steven T., Yende, Sachin

Objectives: Severe infections, often requiring ICU admission, have been associated with persistent cognitive dysfunction. Less severe infections are more common and whether they are associated with an increased risk of dementia is unclear. We determined the association of pneumonia hospitalization with risk of dementia in well-functioning older adults.; Design: Secondary analysis of a randomized multicenter […]

Rosas, H. D., Doros, G., Gevorkian, S., Malarick, K., Reuter, M., Coutu, J.-P., Triggs, T. D., Wilkens, P. J., Matson, W., Salat, D. H., Hersch, S. M.

Objective: To assess the safety and tolerability of high-dose creatine, the feasibility of enrolling premanifest and 50% at-risk subjects in a prevention trial, and the potential of cognitive, imaging, and blood markers.; Methods: Sixty-four eligible consenting participants were randomly allocated (1:1) to 15 g twice daily of creatine monohydrate or placebo for a 6-month double-blind […]

Martínez-Lapiscina, Elena H, Clavero, Pedro, Toledo, Estefania, Estruch, Ramon, Salas-Salvadó, Jordi, San Julián, Beatriz, Sanchez-Tainta, Ana, Ros, Emilio, Valls-Pedret, Cinta, Martinez-Gonzalez, Miguel Á

Objective: Previous observational studies reported beneficial effects of the Mediterranean diet (MedDiet) on cognitive function, but results were inconsistent. We assessed the effect on cognition of a nutritional intervention using MedDiets in comparison with a low-fat control diet. Methods: We assessed 522 participants at high vascular risk (44.6% men, age 74.6 ± 5.7 years at […]