Iwasaki, Koh, Kosaka, Kenji, Mori, Hideo, Okitsu, Reina, Furukawa, Katsutoshi, Manabe, Yuta, Yoshita, Mitsuhiro, Kanamori, Aya, Ito, Nobuo, Wada, Kenji, Kitayama, Michio, Horiguchi, Jun, Yamaguchi, Shuhei, Takayama, Shin, Fukuhara, Ryuji, Ouma, Shinji, Nakano, Seigo, Hashimoto, Mamoru, Kinoshita, Toru

Background: This multicentre open-label trial examined the efficacy and safety of the traditional Japanese medicine, or Kampo medicine, yokukansan (YKS), for behavioural and psychological symptoms of dementia (BPSD) in patients with dementia with Lewy bodies.; Methods: Sixty-three dementia with Lewy bodies patients with probable BPSD (M:W, 30:33; mean age, 78.2±5.8 years) were enrolled and treated […]

Satoh, Masayuki, Ishikawa, Hiroyasu, Meguro, Kenichi, Kasuya, Masashi, Ishii, Hiroshi, Yamaguchi, Satoshi

Deficits in the cholinergic system are pronounced in dementia with Lewy bodies (DLB) and are more severe in patients with visual hallucinations (VHs). The aim is to identify the occipital glucose metabolism patterns by positron emission tomography (PET) and the changes following donepezil treatment. 13 DLB patients with VHs were enrolled in the study. After […]

Cummings, Jeffrey, Emre, Murat, Aarsland, Dag, Tekin, Sibel, Dronamraju, Nalina, Lane, Roger

Hallucinations in Alzheimer’s disease (AD) may indicate greater cortical cholinergic deficits. Rivastigmine has shown larger treatment benefits versus placebo in dementia with Lewy bodies and Parkinson’s disease dementia patients with hallucinations. In this retrospective, hypothesis-generating analysis, we investigated whether hallucinations in AD were associated with greater treatment benefits with rivastigmine. Data were pooled from two […]

Kurita, Akira, Murakami, Maiko, Takagi, Satoshi, Matsushima, Masato, Suzuki, Masahiko

Visual hallucinations (VHs) are common in dementia with Lewy bodies (DLB) and Parkinson’s disease with dementia (PDD), while auditory hallucinations are rare. To neurophysiologically investigate the pathophysiology of VHs in these disorders, we studied event-related potentials (ERPs) of DLB, PDD, and Alzheimer’s disease (AD) patients. We compared visual and auditory ERP latencies among PDD patients […]